In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 97, No. 21 ( 2000-10-10), p. 11478-11481
Abstract:
Emphysema is a pulmonary disease characterized by alveolar wall
destruction, resulting in enlargement of gas exchange spaces without fibrosis. This condition is a part of chronic obstructive pulmonary
disease (COPD), which causes 3.5% of deaths worldwide [Anonymous (1990) World Health Stat. Q. Special ,
1–51] and contributes greatly to the global burden of disease
[Murray, C. J. & Lopez, A. D. (1996) Science 274, 740–743]. Alveolar regeneration has been shown in animal models and could have potential for clinical treatment of early-stage
emphysema. However, current techniques for detection of emphysema are not sensitive at the initial stages. Early-stage human panacinar
emphysema is modeled in elastase-treated animals. Here, we provide an in vivo imaging method for differentiating normal and
emphysematous rat lungs by measuring the apparent diffusion coefficient (ADC) of hyperpolarized 3 He by using magnetic resonance
imaging. These data show that the ADC is significantly larger in elastase-treated rats, indicating alveolar expansion. Whereas these
rats were clinically asymptomatic, conventional histology confirmed presence of injury. Our results indicate that measurement of the
hyperpolarized 3 He ADC can be a valuable research tool and
has potential application in the clinical setting.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.97.21.11478
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2000
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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