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  • 1
    Online Resource
    Online Resource
    BFG: privacy protection framework for internet of medical things based on blockchain and federated learning
    Informa UK Limited ; 2023
    In:  Connection Science Vol. 35, No. 1 ( 2023-12-31)
    Details
    In: Connection Science, Informa UK Limited, Vol. 35, No. 1 ( 2023-12-31)
    Type of Medium: Online Resource
    ISSN: 0954-0091 , 1360-0494
    URL: Article
    DOI: 10.1080/09540091.2023.2199951
    RVK:
    CL 1000
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 1501040-5
    SSG: 7,11
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  • 2
    Online Resource
    Online Resource
    Citation theories in the framework of international flow of information: New evidence with translation analysis
    Wiley ; 1997
    In:  Journal of the American Society for Information Science Vol. 48, No. 1 ( 1997-01), p. 80-87
    Details
    In: Journal of the American Society for Information Science, Wiley, Vol. 48, No. 1 ( 1997-01), p. 80-87
    Type of Medium: Online Resource
    ISSN: 0002-8231 , 1097-4571
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/(SICI)1097-4571(199701)48:1〈〉1.0.CO;2-P
    DOI: 10.1002/(ISSN)1097-4571
    DOI: 10.1002/(SICI)1097-4571(199701)48:1〈80::AID-ASI9〉3.0.CO;2-Y
    Language: English
    Publisher: Wiley
    Publication Date: 1997
    detail.hit.zdb_id: 3156-2
    detail.hit.zdb_id: 2756770-9
    detail.hit.zdb_id: 1473755-3
    detail.hit.zdb_id: 2755710-8
    SSG: 24,1
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  • 3
    Online Resource
    Online Resource
    Gender differences in the online reading environment
    Emerald ; 2008
    In:  Journal of Documentation Vol. 64, No. 4 ( 2008-07-25), p. 616-626
    Details
    In: Journal of Documentation, Emerald, Vol. 64, No. 4 ( 2008-07-25), p. 616-626
    Abstract: The purpose of this study is to explore gender differences in the online reading environment. Design/methodology/approach Survey and analysis methods are employed. Findings Survey results reveal that female readers have a stronger preference for paper as a reading medium than male readers, whereas male readers exhibit a greater degree of satisfaction with online reading than females. Additionally, males and females differ significantly on the dimension of selective reading and sustained attention. Originality/value Understanding gender differences would enable a better understanding of the changing reading behavior in the online environment, and to develop more effective digital reading devices. Factors affecting gender differences in the online reading environment are discussed, and directions for future research are suggested.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/00220410810884101
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 2008
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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  • 4
    Online Resource
    Online Resource
    Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients
    Proceedings of the National Academy of Sciences ; 2021
    In:  Proceedings of the National Academy of Sciences Vol. 118, No. 11 ( 2021-03-16)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 118, No. 11 ( 2021-03-16)
    Abstract: Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non–small cell lung cancer (NSCLC) patients using epithelial marker–based detection approaches despite the aggressive nature of NSCLC. Here, we demonstrate hexokinase-2 (HK2) as a metabolic function–associated marker for the detection of CTCs. In 59 NSCLC patients bearing cytokeratin-positive (CK pos ) primary tumors, HK2 enables resolving cytokeratin-negative (HK2 high /CK neg ) CTCs as a prevalent population in about half of the peripheral blood samples with positive CTC counts. However, HK2 high /CK neg tumor cells are a minority population in pleural effusions and cerebrospinal fluids. Single-cell analysis shows that HK2 high /CK neg CTCs exhibit smaller sizes but consistent copy number variation profiles compared with CK pos counterparts. Single-cell transcriptome profiling reveals that CK expression levels of CTCs are independent of their epithelial-to-mesenchymal transition (EMT) status, challenging the long-standing association between CK expression and EMT. HK2 high /CK neg CTCs display metastasis and EGFR inhibitor resistance-related molecular signatures and are selectively enriched in patients with EGFR L858R driver oncogene mutation as opposed to EGFR 19Del , which is more frequently found in patients with prevalent CK pos CTCs in the blood. Consistently, treatment-naïve patients with a larger number or proportion of HK2 high /CK neg CTCs in the blood exhibit poor therapy response and shorter progression-free survival. Collectively, our approach resolves a more complete spectrum of CTCs in NSCLC that can potentially be exploited to identify patient prognosis before therapy.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2012228118
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth
    Proceedings of the National Academy of Sciences ; 2017
    In:  Proceedings of the National Academy of Sciences Vol. 114, No. 48 ( 2017-11-28), p. 12791-12796
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 114, No. 48 ( 2017-11-28), p. 12791-12796
    Abstract: Metastasis is a major cause of cancer-related deaths. Approximately 80% of patients with colorectal cancer develop liver metastasis and 20% develop lung metastasis. We found that at different stages of colon cancer, IFNγ secretion from peripheral blood mononuclear cells was decreased compared with healthy controls. The ribosomal S6 kinase (RSK) family of kinases has multiple cellular functions, and we examined their roles in this observed IFNγ decrease. Flow cytometry analysis of wild-type (WT) and RSK2 knockout (KO) mice revealed significantly lower levels of IFNγ in the RSK2 KO mice compared with the WT mice. Since IFNγ is a component of immunity, which contributes to protection against metastatic carcinomas, we conducted a colon cancer liver metastasis experiment. We found significantly greater metastasis in RSK2 KO mice compared with WT mice. Transcription factor T-bet can directly activate Ifnγ gene transcription. In vitro kinase assay results showed that RSK2 phosphorylated T-bet at serines 498 and 502. We show that phosphorylation of T-bet by RSK2 is required for IFNγ expression, because knockdown of RSK2 expression or overexpression of mutant T-bet reduces IFNγ mRNA expression. To verify the function of the phosphorylation sites, we overexpressed a constitutively active mutant T-bet (S498E/S502E) in bone marrow. Mutant T-bet restored the IFNγ mRNA levels and dramatically reduced the metastasis rate in these mice. Overall, these results indicate that phosphorylation of T-bet is required for the inhibition of colon cancer metastasis and growth through a positive regulation of RSK2/T-bet/IFNγ signaling.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1710756114
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Reading in the age of digital distraction
    Emerald ; 2022
    In:  Journal of Documentation Vol. 78, No. 6 ( 2022-10-04), p. 1201-1212
    Details
    In: Journal of Documentation, Emerald, Vol. 78, No. 6 ( 2022-10-04), p. 1201-1212
    Abstract: Digital distraction is a common phenomenon in e-reading contexts, and it is worth exploring in depth from the perspectives of information (digital content), users (readers) and technology (digital reading medium). Since screen reading has close links with multitasking and potential distraction, any investigation of reading in the digital environment must factor in this reality. This paper aims to investigate the extent and effects of digital distraction while reading on screens. Special emphases go to exploring multitasking while reading. Design/methodology/approach Survey and analysis methods are employed. Findings The extent of digital distraction among college students it found is alarming. All the top four sources of distraction are communication-based activities. Female students tend to concentrate more than males when they read on screens. An overwhelming majority of participants choose to read in print to reduce distractions and to concentrate effectively. Screen reading is inherently distracting, primarily due to multitasking. It appears that repeated multitasking during academic endeavors carries substantial costs. Originality/value Implications of digital distraction are discussed, and directions of future research are suggested.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/JD-07-2021-0130
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 2022
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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  • 7
    Online Resource
    Online Resource
    Changing behaviour in the transborder information flow under different political circumstances
    Emerald ; 1997
    In:  Journal of Documentation Vol. 53, No. 4 ( 1997-10-01), p. 374-383
    Details
    In: Journal of Documentation, Emerald, Vol. 53, No. 4 ( 1997-10-01), p. 374-383
    Abstract: Global communication cannot be understood without taking international relations into account, since both are so dynamically intertwined that it is impossible to explore international information flow without looking at the political realities. In this article, content and translation in Chinese library and information science literature in different political circumstances (1890‐1949; 1949‐1962; 1963‐1976; 1977‐1989) were used to examine the changing behaviour in trans‐ border information flow. It was found that transborder information flow is dynamic and the direction of flow is heavily influenced by the political realities.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/EUM0000000007203
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 1997
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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  • 8
    Online Resource
    Online Resource
    The evolution of documents and its impacts
    Emerald ; 2004
    In:  Journal of Documentation Vol. 60, No. 3 ( 2004-06-01), p. 279-288
    Details
    In: Journal of Documentation, Emerald, Vol. 60, No. 3 ( 2004-06-01), p. 279-288
    Abstract: This article examines the evolution of documents and its impacts from the following aspects: information density, longevity, uniqueness, duplicability, mobility, connectivity, and integration. It focuses on the consequences of the shift from printed media to digital media. By looking back on their evolution, we are able to see how the notions and functions of documents change over time, and the resulting impacts on individuals, organizations, and society.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/00220410410534185
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 2004
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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  • 9
    Online Resource
    Online Resource
    Reading behavior in the digital environment : Changes in reading behavior over the past ten years
    Emerald ; 2005
    In:  Journal of Documentation Vol. 61, No. 6 ( 2005-12-01), p. 700-712
    Details
    In: Journal of Documentation, Emerald, Vol. 61, No. 6 ( 2005-12-01), p. 700-712
    Abstract: This study attempts to investigate reading behavior in the digital environment by analyzing how people's reading behavior has changed over the past ten years. Design/methodology/approach Survey and analysis methods are employed. Findings With an increasing amount of time spent reading electronic documents, a screen‐based reading behavior is emerging. The screen‐based reading behavior is characterized by more time spent on browsing and scanning, keyword spotting, one‐time reading, non‐linear reading, and reading more selectively, while less time is spent on in‐depth reading, and concentrated reading. Decreasing sustained attention is also noted. Annotating and highlighting while reading is a common activity in the printed environment. However, this “traditional” pattern has not yet migrated to the digital environment when people read electronic documents. Originality/value Implications for the changes in reading behavior are discussed, and directions for future research are suggested.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/00220410510632040
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 2005
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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  • 10
    Online Resource
    Online Resource
    The effects of social media addiction on reading practice: a survey of undergraduate students in China
    Emerald ; 2023
    In:  Journal of Documentation Vol. 79, No. 3 ( 2023-04-04), p. 670-682
    Details
    In: Journal of Documentation, Emerald, Vol. 79, No. 3 ( 2023-04-04), p. 670-682
    Abstract: The prevalence of digital reading and the widespread use of social media among young people demands systematic exploration of the effects of social media addiction on students' reading practice. This paper aims to explore the effects of social media addiction on reading preferences, in-depth reading and sustained attention. Design/methodology/approach Survey and analysis methods are employed. Findings For many, social media provides an ideal platform of connection and expression; however, prolonged social media use holds the danger of becoming a behavioral addiction that threatens to undermine one's reading practice. Social media use tends to have a more significant impact on leisure reading than on academic reading. Obsessive engagement with social media hurts reading concentration and in-depth reading. While a majority (70.4%) of those surveyed believed that chronic social media use carries more harm than good on their learning, only half (50.1%) agreed or strongly agreed that today's students are too indulged in social media and need forceful control of it. Originality/value Implications of the effects of social media on reading practice are discussed, and directions for future research are suggested. It is likely that social media will continue to be seductive, attracting new generations of young people. Future research should explore prevention strategies.
    Type of Medium: Online Resource
    ISSN: 0022-0418
    URL: Article
    DOI: 10.1108/JD-05-2022-0111
    RVK:
    AN 10100
    Language: English
    Publisher: Emerald
    Publication Date: 2023
    detail.hit.zdb_id: 3021-1
    detail.hit.zdb_id: 1479864-5
    SSG: 24,1
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