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  • 1
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2015
    In:  Science Vol. 349, No. 6249 ( 2015-08-14), p. 696-696
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 349, No. 6249 ( 2015-08-14), p. 696-696
    Abstract: Since the first formulations of quantum mechanics in the early 20th century, it became clear that the enormous complexity of quantum-mechanical systems presented intractable computational problems. Richard Feynman was the first to turn this problem on its head. He asked whether we could exploit this quantum complexity to construct a computer based on these same quantum mechanical principles, offering exponential algorithmic improvements, and whether such a computer could efficiently simulate quantum systems that our classical computers are unable to simulate. This challenge initiated the field of quantum computing and is today a major field of research in the physics and computer science communities. One hurdle has been to construct devices that match the flexible programmability of classical computers. On page 711 of this issue, Carolan et al. ( 1 ) present a step in that direction, a fully reconfigurable optical waveguide circuit that can be programmed to implement arbitrary linear optics transformations on up to six optical modes.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    RVK:
    RVK:
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2015
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 1992
    In:  The Journal of the Acoustical Society of America Vol. 91, No. 5 ( 1992-05-01), p. 2539-2543
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 91, No. 5 ( 1992-05-01), p. 2539-2543
    Abstract: In direct analogy to the electronic band structure found in semiconductors and the photonic bands for light in a medium with a periodic dielectric constant, a periodic density variation in a fluid can give rise to sonic frequency passbands and band gaps. Hence, a fluid medium can be constructed that prohibits sound propagation at certain frequencies while allowing practically free propagation at others. The effect of a sonic band medium on a monopole acoustic source is discussed in a simple one-dimensional model. In particular, the complete quenching of radiated power is seen for a harmonic radiator at a frequency that corresponds to a band gap—in analogy with a similar effect that is predicted for the atomic emission of electromagnetic waves in a photonic band structure. The ability to construct a medium that selectively prohibits sound propagation and emission in a certain range of frequencies, while allowing transmission and enhanced radiation rates at others, could have interesting practical applications.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1992
    detail.hit.zdb_id: 1461063-2
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  • 3
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2009
    In:  Science Vol. 325, No. 5938 ( 2009-07-17), p. 269-269
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 325, No. 5938 ( 2009-07-17), p. 269-269
    Abstract: Weaving her narrative around a series of imagined face-to-face dialogues, Gilder offers an account of the development of quantum physics that pays particular attention to developments through the second half of the 20th century.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    RVK:
    RVK:
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2009
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 1995
    In:  The Journal of the Acoustical Society of America Vol. 98, No. 5_Supplement ( 1995-11-01), p. 2922-2922
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 98, No. 5_Supplement ( 1995-11-01), p. 2922-2922
    Abstract: Observations and measurements are reported of trains of traveling-wave pressure impulses that are coincident with the onset of stable, synchronous sonoluminescence. Each pressure impulse is initiated by a hard collapse of the centered bubble, travels outward to the flask boundary, is reflected, and then reconverges. The converging impulse apparently rebounds from the free boundary of the bubble and the impulse continues traveling outward and inward until it is synchronized with a subsequent collapse. It is hypothesized that synchronous sonoluminescence is produced when this train of spherically symmetric, concentric pressure traveling impulses are synchronized with the driving standing wave. Experimental observations of integral numbers of such impulses for a number of spherical flasks at several harmonics support this hypothesis. Theoretical analyses of these experimental observations and measurements will be presented.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1995
    detail.hit.zdb_id: 1461063-2
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  • 5
    In: Brain, Oxford University Press (OUP), Vol. 146, No. 6 ( 2023-06-01), p. 2285-2297
    Abstract: The blood–brain barrier ensures CNS homeostasis and protection from injury. Claudin-5 (CLDN5), an important component of tight junctions, is critical for the integrity of the blood–brain barrier. We have identified de novo heterozygous missense variants in CLDN5 in 15 unrelated patients who presented with a shared constellation of features including developmental delay, seizures (primarily infantile onset focal epilepsy), microcephaly and a recognizable pattern of pontine atrophy and brain calcifications. All variants clustered in one subregion/domain of the CLDN5 gene and the recurrent variants demonstrate genotype–phenotype correlations. We modelled both patient variants and loss of function alleles in the zebrafish to show that the variants analogous to those in patients probably result in a novel aberrant function in CLDN5. In total, human patient and zebrafish data provide parallel evidence that pathogenic sequence variants in CLDN5 cause a novel neurodevelopmental disorder involving disruption of the blood–brain barrier and impaired neuronal function.
    Type of Medium: Online Resource
    ISSN: 0006-8950 , 1460-2156
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1474117-9
    SSG: 12
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