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  • 1
    Online Resource
    Online Resource
    Informa UK Limited ; 2012
    In:  Cultura y Educación Vol. 24, No. 1 ( 2012-01), p. 33-43
    In: Cultura y Educación, Informa UK Limited, Vol. 24, No. 1 ( 2012-01), p. 33-43
    Type of Medium: Online Resource
    ISSN: 1135-6405 , 1578-4118
    Language: Spanish
    Publisher: Informa UK Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2083692-2
    SSG: 7,11
    SSG: 5,3
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  • 2
    In: Brain, Oxford University Press (OUP), Vol. 143, No. 6 ( 2020-06-01), p. 1746-1765
    Abstract: TOR1A/TorsinA mutations cause two incurable diseases: a recessive congenital syndrome that can be lethal, and a dominantly-inherited childhood-onset dystonia (DYT-TOR1A). TorsinA has been linked to phosphatidic acid lipid metabolism in Drosophila melanogaster. Here we evaluate the role of phosphatidic acid phosphatase (PAP) enzymes in TOR1A diseases using induced pluripotent stem cell-derived neurons from patients, and mouse models of recessive Tor1a disease. We find that Lipin PAP enzyme activity is abnormally elevated in human DYT-TOR1A dystonia patient cells and in the brains of four different Tor1a mouse models. Its severity also correlated with the dosage of Tor1a/TOR1A mutation. We assessed the role of excess Lipin activity in the neurological dysfunction of Tor1a disease mouse models by interbreeding these with Lpin1 knock-out mice. Genetic reduction of Lpin1 improved the survival of recessive Tor1a disease-model mice, alongside suppressing neurodegeneration, motor dysfunction, and nuclear membrane pathology. These data establish that TOR1A disease mutations cause abnormal phosphatidic acid metabolism, and suggest that approaches that suppress Lipin PAP enzyme activity could be therapeutically useful for TOR1A diseases.
    Type of Medium: Online Resource
    ISSN: 0006-8950 , 1460-2156
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1474117-9
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  Language and Speech Vol. 64, No. 4 ( 2021-12), p. 900-929
    In: Language and Speech, SAGE Publications, Vol. 64, No. 4 ( 2021-12), p. 900-929
    Abstract: The neural/mental operations involved in the process of visual word recognition (VWR) are fundamental for the efficient comprehension of written/printed words during reading. The present study used CiteSpace, a visual analysis software, to identify the intellectual landscape where VWR has been reviewed in the past decade. Thus, synthesized co-citation networks were analyzed to explore and discuss the main questions raised in the VWR literature: the research fronts and the emerging trends of research on this topic. Our results showed that the main questions addressed in VWR studies during the last decade have been focused on four main aspects related to “what,” “where,” “when,” and “how” of VWR; to be specific, the different types of representations assessed during VWR (“what”), the locations and the timing of the brain activity involved in VWR (“where” and “when”), and the interactivity among different representations during processing (“how”). Among the revised studies, letter position coding was found to be the main topic of interest, possibly reflecting the critical role of this process. Furthermore, the evidence found in these studies consistently supported that VWR implies access to phonological, semantic, and morphological representations, which interact and modulate the processing of written words, particularly during early stages. Altogether, our findings showed the evolution in VWR literature regarding the different cognitive and neural operations involved in this process, highlighting the growing interest over the last decade toward the top-down way that mental representations interact.
    Type of Medium: Online Resource
    ISSN: 0023-8309 , 1756-6053
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2001596-3
    SSG: 5,2
    SSG: 7,11
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  • 4
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2022
    In:  Linguistics Vol. 60, No. 4 ( 2022-07-26), p. 1149-1167
    In: Linguistics, Walter de Gruyter GmbH, Vol. 60, No. 4 ( 2022-07-26), p. 1149-1167
    Abstract: The endings of Spanish nouns reflect gender with varying degrees of frequency and regularity. The most common and regular endings are -o for masculine nouns and -a for feminine nouns, - o being more frequent and less closely associated with a specific gender category (masculine) than -a . Pairs of words occurring with both gender categories differ in the frequencies with which they are used as masculine or feminine forms: médic-o/médic-a ‘doctor’ (m.)/‘doctor’ (f.) is a clear example of a masculine-dominant pair, whereas enfermer-o/enfermer-a ‘nurse’ (m.)/ ‘nurse’ (f.) is a feminine-dominant pair. Adult readers of Spanish are faster in recognizing feminine forms of feminine-dominant pairs, and masculine forms of masculine-dominant pairs (Dominguez, Alberto, Fernando Cuetos & Juan Segui. 1999. The processing of grammatical gender and number in Spanish. Journal of Psycholinguistic Research 28(5). 485–498). This study aims to test the dominant frequency effect in third and sixth grade children, as well as in adults. Children were faster in recognizing masculine forms in masculine-dominant pairs, but not feminine forms in feminine-dominant pairs. Adults, by contrast, tended to respond faster to higher frequency words, irrespective of gender, indicating that they have independent representations for both genders. The dominance of masculine forms in children could be a consequence of the statistical distribution of gender dominance and regularity in Spanish. The experience of skilled adult readers seems to make them less dependent on this statistical pattern.
    Type of Medium: Online Resource
    ISSN: 0024-3949 , 1613-396X
    RVK:
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 1469023-8
    detail.hit.zdb_id: 3382-0
    SSG: 7,11
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  • 5
    In: Studies in Second Language Acquisition, Cambridge University Press (CUP)
    Abstract: The present study investigates bilinguals’ capacity to rapidly establish memory traces for novel word forms in a second language (L2), as a function of L2 linguistic proficiency. A group of Chinese-English bilinguals with various English proficiency levels were presented with a reading-aloud task, consisting of 16 pseudowords and 16 English words repeatedly presented across six training exposures. Behavioral and neurophysiological data were collected, and modulations in the word-length effect across repetitions were measured as an index of transition from sublexical to lexical involvement. Results revealed that higher L2 proficiency was associated with decreased word-length effect on novel words, reflected in both naming latencies and early N1 and P200 brain responses. In contrast, lower proficiency learners appeared to engage in effortful letter-to-sound decoding processes, with higher attentional allocation to the letter sequence and greater use of sublexical processing across exposures. Our findings highlight the need to tackle specific grapheme-to-phoneme skills for efficient learning of L2, particularly in populations where the L1 is nonalphabetic.
    Type of Medium: Online Resource
    ISSN: 0272-2631 , 1470-1545
    RVK:
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2023
    detail.hit.zdb_id: 435303-1
    detail.hit.zdb_id: 2002746-1
    SSG: 7,11
    SSG: 5,3
    Location Call Number Limitation Availability
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