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  • 1
    Online Resource
    Online Resource
    Characterization of HPV and host genome interactions in primary head and neck cancers
    Proceedings of the National Academy of Sciences ; 2014
    In:  Proceedings of the National Academy of Sciences Vol. 111, No. 43 ( 2014-10-28), p. 15544-15549
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 111, No. 43 ( 2014-10-28), p. 15544-15549
    Abstract: Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with next generation RNA and DNA sequencing and show that 35 (12.5%) tumors displayed evidence of high-risk HPV types 16, 33, or 35. Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Many of these events involved genes with documented roles in cancer. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1416074111
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2014
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  • 2
    Online Resource
    Online Resource
    Reflection phase dispersion editing generates wideband invisible acoustic Huygens's metasurface
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 146, No. 1 ( 2019-07-01), p. 166-171
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 146, No. 1 ( 2019-07-01), p. 166-171
    Abstract: Acoustic metasurfaces show non-traditional abilities in wave manipulation and provide alternate mechanisms for information communication and invisibility technology. However, most of the mechanisms remain narrow band (relative bandwidth ∼5%), and a wideband trait is essential for engineering applications. For example, controllable effective material properties—reflection or transmission phase—has barely been realized in wideband because the intrinsic dispersion relation is not always editable. In this paper, wideband reflection phase editing is realized, and wideband invisibility of a phase preserved Huygens's metasurface on a flat background is achieved with anomalous reflection. This metasurface is built with proposed unsymmetrical twin Helmholtz resonators which reach a predefined dispersion relation target value. The total instantaneous acoustic fields show nearly identical carpeting effects in a consecutive band with relative bandwidth 52.1% (from 5400 to 9200 Hz) in simulation and experiment.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5116012
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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  • 3
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    Online Resource
    Boosting Chinese Question Answering with Two Lightweight Methods : ABSPs and SCO-QAT
    Association for Computing Machinery (ACM) ; 2008
    In:  ACM Transactions on Asian Language Information Processing Vol. 7, No. 4 ( 2008-11), p. 1-29
    Details
    In: ACM Transactions on Asian Language Information Processing, Association for Computing Machinery (ACM), Vol. 7, No. 4 ( 2008-11), p. 1-29
    Abstract: Question Answering (QA) research has been conducted in many languages. Nearly all the top performing systems use heavy methods that require sophisticated techniques, such as parsers or logic provers. However, such techniques are usually unavailable or unaffordable for under-resourced languages or in resource-limited situations. In this article, we describe how a top-performing Chinese QA system can be designed by using lightweight methods effectively. We propose two lightweight methods, namely the Sum of Co-occurrences of Question and Answer Terms (SCO-QAT) and Alignment-based Surface Patterns (ABSPs). SCO-QAT is a co-occurrence-based answer-ranking method that does not need extra knowledge, word-ignoring heuristic rules, or tools. It calculates co-occurrence scores based on the passage retrieval results. ABSPs are syntactic patterns trained from question-answer pairs with a multiple alignment algorithm. They are used to capture the relations between terms and then use the relations to filter answers. We attribute the success of the ABSPs and SCO-QAT methods to the effective use of local syntactic information and global co-occurrence information. By using SCO-QAT and ABSPs, we improved the RU-Accuracy of our testbed QA system, ASQA, from 0.445 to 0.535 on the NTCIR-5 dataset. It also achieved the top 0.5 RU-Accuracy on the NTCIR-6 dataset. The result shows that lightweight methods are not only cheaper to implement, but also have the potential to achieve state-of-the-art performances.
    Type of Medium: Online Resource
    ISSN: 1530-0226 , 1558-3430
    URL: Article
    DOI: 10.1145/1450295.1450297
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2008
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    detail.hit.zdb_id: 2078715-7
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  • 4
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    Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad
    Proceedings of the National Academy of Sciences ; 2008
    In:  Proceedings of the National Academy of Sciences Vol. 105, No. 10 ( 2008-03-11), p. 3927-3932
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 105, No. 10 ( 2008-03-11), p. 3927-3932
    Abstract: Interstitial flow in and around tumor tissue affects the mechanical microenvironment to modulate tumor cell growth and metastasis. We investigated the roles of flow-induced shear stress in modulating cell cycle distribution in four tumor cell lines and the underlying mechanisms. In all four cell lines, incubation under static conditions for 24 or 48 h led to G 0 /G 1 arrest; in contrast, shear stress (12 dynes/cm 2 ) induced G 2 /M arrest. The molecular basis of the shear effect was analyzed, and the presentation on molecular mechanism is focused on human MG63 osteosarcoma cells. Shear stress induced increased expressions of cyclin B1 and p21 CIP1 and decreased expressions of cyclins A, D1, and E, cyclin-dependent protein kinases (Cdk)-1, -2, -4, and -6, and p27 KIP1 as well as a decrease in Cdk1 activity. Using specific antibodies and small interfering RNA, we found that the shear-induced G 2 /M arrest and corresponding changes in G 2 /M regulatory protein expression and activity were mediated by α v β 3 and β 1 integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5. Shear stress also down-regulated runt-related transcription factor 2 (Runx2) binding activity and osteocalcin and alkaline phosphatase expressions in MG63 cells; these responses were mediated by α v β 3 and β 1 integrins through Smad5. Our findings provide insights into the mechanism by which shear stress induces G 2 /M arrest in tumor cells and inhibits cell differentiation and demonstrate the importance of mechanical microenvironment in modulating molecular signaling, gene expression, cell cycle, and functions in tumor cells.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0712353105
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2008
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    SSG: 11
    SSG: 12
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  • 5
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    Online Resource
    Satellite-based entanglement distribution over 1200 kilometers
    American Association for the Advancement of Science (AAAS) ; 2017
    In:  Science Vol. 356, No. 6343 ( 2017-06-16), p. 1140-1144
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 356, No. 6343 ( 2017-06-16), p. 1140-1144
    Abstract: Long-distance entanglement distribution is essential for both foundational tests of quantum physics and scalable quantum networks. Owing to channel loss, however, the previously achieved distance was limited to ~100 kilometers. Here we demonstrate satellite-based distribution of entangled photon pairs to two locations separated by 1203 kilometers on Earth, through two satellite-to-ground downlinks with a summed length varying from 1600 to 2400 kilometers. We observed a survival of two-photon entanglement and a violation of Bell inequality by 2.37 ± 0.09 under strict Einstein locality conditions. The obtained effective link efficiency is orders of magnitude higher than that of the direct bidirectional transmission of the two photons through telecommunication fibers.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aan3211
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2017
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
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  • 6
    Online Resource
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    The Controversy of Pepsinogen A/Pepsin A in Detecting Extra-Gastroesophageal Reflux
    Elsevier BV ; 2023
    In:  Journal of Voice Vol. 37, No. 5 ( 2023-09), p. 748-756
    Details
    In: Journal of Voice, Elsevier BV, Vol. 37, No. 5 ( 2023-09), p. 748-756
    Type of Medium: Online Resource
    ISSN: 0892-1997
    URL: Article
    DOI: 10.1016/j.jvoice.2021.04.009
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 17459-2
    SSG: 7,11
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  • 7
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    Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours
    Oxford University Press (OUP) ; 2024
    In:  Brain ( 2024-05-03)
    Details
    In: Brain, Oxford University Press (OUP), ( 2024-05-03)
    Abstract: The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) in depression is a topic of debate, and the underlying mechanisms remain largely unclear. We now elucidate hippocampal excitation-inhibition (E/I) balance underlies the regulatory effects of 5-HT2CR in depression. Molecular biological analyses showed that chronic mild stress (CMS) reduced the expression of 5-HT2CR in hippocampus. We revealed that inhibition of 5-HT2CR induced depressive-like behaviors, reduced GABA release and shifted the E/I balance towards excitation in CA3 pyramidal neurons by using behavioral analyses, microdialysis coupled with mass spectrum, and electrophysiological recording. Moreover, 5-HT2CR modulated neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS (CAPON) interaction through influencing intracellular Ca2+ release, as determined by fiber photometry and coimmunoprecipitation. Notably, disruption of nNOS-CAPON by specific small molecule compound ZLc-002 or AAV-CMV-CAPON-125C-GFP, abolished 5-HT2CR inhibition-induced depressive-like behaviors, as well as the impairment in soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly-mediated GABA vesicle release and a consequent E/I imbalance. Importantly, optogenetic inhibition of CA3 GABAergic neurons prevented the effects of AAV-CMV-CAPON-125C-GFP on depressive behaviors in the presence of 5-HT2CR antagonist. Conclusively, our findings disclose the regulatory role of 5-HT2CR in depressive-like behaviors and highlight the hippocampal nNOS-CAPON coupling-triggered E/I imbalance as a pivotal cellular event underpinning the behavioral consequences of 5-HT2CR inhibition.
    Type of Medium: Online Resource
    ISSN: 0006-8950 , 1460-2156
    URL: Article
    DOI: 10.1093/brain/awae143
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
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    SSG: 12
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  • 8
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    Aging and comprehensive molecular profiling in acute myeloid leukemia
    Proceedings of the National Academy of Sciences ; 2024
    In:  Proceedings of the National Academy of Sciences Vol. 121, No. 10 ( 2024-03-05)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 121, No. 10 ( 2024-03-05)
    Abstract: Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and targeted or whole exome sequencing data were obtained in 94% cases. The correlation of aging-related factors including age and clonal hematopoiesis (CH), gender, and genomic/transcriptomic profiles (gene fusions, genetic mutations, and gene expression networks or pathways) was systematically analyzed. Overall, AML patients aged 60 y and older showed an apparently dismal prognosis. Alongside age, the frequency of gene fusions defined in the World Health Organization classification decreased, while the positive rate of gene mutations, especially CH-related ones, increased. Additionally, the number of genetic mutations was higher in gene fusion–negative (GF-) patients than those with GF. Based on the status of CH- and myelodysplastic syndromes (MDS)-related mutations, three mutant subgroups were identified among the GF- AML cohort, namely, CH-AML, CH-MDS-AML, and other GF- AML. Notably, CH-MDS-AML demonstrated a predominance of elderly and male cases, cytopenia, and significantly adverse clinical outcomes. Besides, gene expression networks including HOXA / B , platelet factors, and inflammatory responses were most striking features associated with aging and poor prognosis in AML. Our work has thus unraveled the intricate regulatory circuitry of interactions among different age, gender, and molecular groups of AML.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2319366121
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2024
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  • 9
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    Four single-machine scheduling problems involving due date determination decisions
    Elsevier BV ; 2013
    In:  Information Sciences Vol. 251 ( 2013-12), p. 164-181
    Details
    In: Information Sciences, Elsevier BV, Vol. 251 ( 2013-12), p. 164-181
    Type of Medium: Online Resource
    ISSN: 0020-0255
    URL: Article
    DOI: 10.1016/j.ins.2013.06.035
    RVK:
    SA 5420
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 218760-7
    SSG: 24,1
    SSG: 7,11
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  • 10
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    Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
    Proceedings of the National Academy of Sciences ; 2005
    In:  Proceedings of the National Academy of Sciences Vol. 102, No. 7 ( 2005-02-15), p. 2430-2435
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 102, No. 7 ( 2005-02-15), p. 2430-2435
    Abstract: The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion from animal to human in this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations. Among them, 17 are polymorphic in palm civets only. The ratio of nonsynonymous/synonymous nucleotide substitution in palm civets collected 1 yr apart from different geographic locations is very high, suggesting a rapid evolving process of viral proteins in civet as well, much like their adaptation in the human host in the early 2002–2003 epidemic. Major genetic variations in some critical genes, particularly the Spike gene, seemed essential for the transition from animal-to-human transmission to human-to-human transmission, which eventually caused the first severe acute respiratory syndrome outbreak of 2002/2003.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0409608102
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2005
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
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