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  • 1
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2012
    In:  Science Vol. 336, No. 6087 ( 2012-06-15), p. 1445-1448
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 336, No. 6087 ( 2012-06-15), p. 1445-1448
    Abstract: Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis . IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    RVK:
    RVK:
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2012
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 2
    In: EPL (Europhysics Letters), IOP Publishing, Vol. 129, No. 3 ( 2020-03-02), p. 37004-
    Type of Medium: Online Resource
    ISSN: 1286-4854
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 1465366-7
    detail.hit.zdb_id: 165776-8
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  • 3
    Online Resource
    Online Resource
    American Speech Language Hearing Association ; 2023
    In:  Journal of Speech, Language, and Hearing Research Vol. 66, No. 10 ( 2023-10-04), p. 4100-4116
    In: Journal of Speech, Language, and Hearing Research, American Speech Language Hearing Association, Vol. 66, No. 10 ( 2023-10-04), p. 4100-4116
    Abstract: This study aimed to examine the developmental trajectory of Mandarin tone identification in quiet and two noisy conditions: speech-shaped noise (SSN) and multitalker babble noise. In addition, we evaluated the relationship between tonal identification development and working memory capacity. Method: Ninety-three typically developing children aged 5–8 years and 23 young adults completed categorical identification of two tonal continua (Tone 1–4 and Tone 2–3) in quiet, SSN, and babble noise. Their working memory was additionally measured using auditory digit span tests. Correlation analyses between digit span scores and boundary widths were performed. Results: Six-year-old children have achieved the adultlike ability of categorical identification of Tone 1–4 continuum under both types of noise. Moreover, 6-year-old children could identify Tone 2–3 continuum as well as adults in SSN. Nonetheless, the child participants, even 8-year-olds, performed worse when tokens from Tone 2–3 continuum were masked by babble noise. Greater working memory capacity was associated with better tone identification in noise for preschoolers aged 5–6 years; however, for school-age children aged 7–8 years, such correlation only existed in Tone 2–3 continuum in SSN. Conclusions: Lexical tone perception might take a prolonged time to achieve adultlike competence in babble noise relative to SSN. Moreover, a significant interaction between masking type and stimulus difficulty was found, as indicated by Tone 2–3 being more susceptible to interference from babble noise than Tone 1–4. Furthermore, correlations between working memory capacity and tone perception in noise varied with developmental stage, stimulus difficulty, and masking type.
    Type of Medium: Online Resource
    ISSN: 1092-4388 , 1558-9102
    Language: English
    Publisher: American Speech Language Hearing Association
    Publication Date: 2023
    detail.hit.zdb_id: 2070420-3
    SSG: 5,2
    SSG: 7,11
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  • 4
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2022
    In:  Proceedings of the National Academy of Sciences Vol. 119, No. 6 ( 2022-02-08)
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 6 ( 2022-02-08)
    Abstract: Organic electrode materials have emerged as promising alternatives to conventional inorganic materials because of their structural diversity and environmental friendliness feature. However, their low energy densities, limited by the single-electron reaction per active group, have plagued the practical applications. Here, we report a nitroaromatic cathode that performs a six-electron reaction per nitro group, drastically improving the specific capacity and energy density compared with the organic electrodes based on single-electron reactions. Based on such a reaction mechanism, the organic cathode of 1,5-dinitronaphthalene demonstrates an ultrahigh specific capacity of 1,338 mAh⋅g −1 and energy density of 3,273 Wh⋅kg −1 , which surpass all existing organic cathodes. The reaction path was verified as a conversion from nitro to amino groups. Our findings open up a pathway, in terms of battery chemistry, for ultrahigh-energy-density Li-organic batteries.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2022
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    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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