In:
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, The Royal Society, Vol. 473, No. 2201 ( 2017-05), p. 20170130-
Abstract:
Light-addressable potentiometric sensors (LAPS) and scanning photo-induced impedance microscopy (SPIM) use photocurrent measurements at electrolyte–insulator–semiconductor substrates for spatio-temporal imaging of electrical potentials and impedance. The techniques have been used for the interrogation of sensor arrays and the imaging of biological systems. Sensor applications range from the detection of different types of ions and the label-free detection of charged molecules such as DNA and proteins to enzyme-based biosensors. Imaging applications include the temporal imaging of extracellular potentials and dynamic concentration changes in microfluidic channels and the lateral imaging of cell surface charges and cell metabolism. This paper will investigate the current state of the art of the measurement technology with a focus on spatial and temporal resolution and review the biological applications, these techniques have been used for. An outlook on future developments in the field will be given.
Type of Medium:
Online Resource
ISSN:
1364-5021
,
1471-2946
DOI:
10.1098/rspa.2017.0130
Language:
English
Publisher:
The Royal Society
Publication Date:
2017
detail.hit.zdb_id:
209241-4
detail.hit.zdb_id:
1460987-3
SSG:
11
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