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  • 1
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2018
    In:  Proceedings of the National Academy of Sciences Vol. 115, No. 17 ( 2018-04-24)
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 115, No. 17 ( 2018-04-24)
    Abstract: Lung cancer is the leading cause of cancer-related death worldwide. Inactivation of tumor suppressor genes (TSGs) promotes lung cancer malignant progression. Here, we take advantage of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated somatic gene knockout in a Kras G12D/ + mouse model to identify bona fide TSGs. From individual knockout of 55 potential TSGs, we identify five genes, including Utx , Ptip , Acp5 , Acacb , and Clu , whose knockout significantly promotes lung tumorigenesis. These candidate genes are frequently down-regulated in human lung cancer specimens and significantly associated with survival in patients with lung cancer. Through crossing the conditional Utx knockout allele to the Kras G12D/ + mouse model, we further find that Utx deletion dramatically promotes lung cancer progression. The tumor-promotive effect of Utx knockout in vivo is mainly mediated through an increase of the EZH2 level, which up-regulates the H3K27me3 level. Moreover, the Utx -knockout lung tumors are preferentially sensitive to EZH2 inhibitor treatment. Collectively, our study provides a systematic screening of TSGs in vivo and identifies UTX as an important epigenetic regulator in lung tumorigenesis.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2018
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    IOP Publishing ; 2018
    In:  EPL (Europhysics Letters) Vol. 123, No. 3 ( 2018-09-10), p. 36003-
    In: EPL (Europhysics Letters), IOP Publishing, Vol. 123, No. 3 ( 2018-09-10), p. 36003-
    Type of Medium: Online Resource
    ISSN: 1286-4854
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2018
    detail.hit.zdb_id: 1465366-7
    detail.hit.zdb_id: 165776-8
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  • 3
    In: Psychophysiology, Wiley, Vol. 52, No. 4 ( 2015-04), p. 562-571
    Abstract: The present study examined electroencephalogram profiles on a novel stimulus‐response compatibility ( SRC ) task in order to elucidate the distinct brain mechanisms of stimulus‐stimulus ( S ‐ S ) and stimulus‐response ( S ‐ R ) conflict processing. The results showed that the SRC effects on reaction times ( RT s) and N 2 amplitudes were additive when both S ‐ S and S ‐ R conflicts existed. We also observed that, for both RT s and N 2 amplitudes, the conflict adaptation effects—the reduced SRC effect following an incongruent trial versus a congruent trial—were present only when two consecutive trials involved the same type of conflict. Time‐frequency analysis revealed that both S ‐ S and S ‐ R conflicts modulated power in the theta band, whereas S ‐ S conflict additionally modulated power in the alpha and beta bands. In summary, our findings provide insight into the domain‐specific conflict processing and the modular organization of cognitive control.
    Type of Medium: Online Resource
    ISSN: 0048-5772 , 1469-8986
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1484299-3
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2018
    In:  IEEE/ACM Transactions on Audio, Speech, and Language Processing Vol. 26, No. 2 ( 2018-2), p. 296-303
    In: IEEE/ACM Transactions on Audio, Speech, and Language Processing, Institute of Electrical and Electronics Engineers (IEEE), Vol. 26, No. 2 ( 2018-2), p. 296-303
    Type of Medium: Online Resource
    ISSN: 2329-9290 , 2329-9304
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018
    detail.hit.zdb_id: 2751224-1
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  • 5
    Online Resource
    Online Resource
    The Royal Society ; 2016
    In:  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences Vol. 472, No. 2195 ( 2016-11), p. 20160682-
    In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, The Royal Society, Vol. 472, No. 2195 ( 2016-11), p. 20160682-
    Abstract: A generic degree-4 vertex (4-vertex) origami possesses one continuous degree-of-freedom for rigid folding, and this folding process can be stopped when two of its facets bind together. Such facet-binding will induce self-locking so that the overall structure stays at a pre-specified configuration without additional locking elements or actuators. Self-locking offers many promising properties, such as programmable deformation ranges and piecewise stiffness jumps, that could significantly advance many adaptive structural systems. However, despite its excellent potential, the origami self-locking features have not been well studied, understood, and used. To advance the state of the art, this research conducts a comprehensive investigation on the principles of achieving and harnessing self-locking in 4-vertex origami structures. Especially, for the first time, this study expands the 4-vertex structure construction from single-component to dual-component designs and investigates their self-locking behaviours. By exploiting various tessellation designs, this research discovers that the dual-component designs offer the origami structures with extraordinary attributes that the single-component structures do not have, which include the existence of flat-folded locking planes, programmable locking points and deformability. Finally, proof-of-concept experiments investigate how self-locking can effectively induce piecewise stiffness jumps. The results of this research provide new scientific knowledge and a systematic framework for the design, analysis and utilization of self-locking origami structures for many potential engineering applications.
    Type of Medium: Online Resource
    ISSN: 1364-5021 , 1471-2946
    Language: English
    Publisher: The Royal Society
    Publication Date: 2016
    detail.hit.zdb_id: 209241-4
    detail.hit.zdb_id: 1460987-3
    SSG: 11
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  • 6
    In: Psychophysiology, Wiley, Vol. 56, No. 4 ( 2019-04)
    Abstract: Human performance is determined by interactions of multiple frames of reference (FOR)‐based representations. However, the neural mechanism of conflict processing among these FORs is unclear. Our work is the first to explore the neural mechanism of processing multiple FOR‐based conflicts using EEG. The results indicated that, although the processing of multiple FOR‐based conflicts differed in temporal and spectral dynamics in an early phase, they shared considerable ERP and time‐frequency properties in a late phase. Our findings thus highlight the existence of two specific conflict monitoring systems and a general executive control system for the resolution of FOR‐based conflicts.
    Type of Medium: Online Resource
    ISSN: 0048-5772 , 1469-8986
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1484299-3
    SSG: 5,2
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