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  • 1
    Online Resource
    Online Resource
    IOP Publishing ; 2019
    In:  EPL (Europhysics Letters) Vol. 125, No. 3 ( 2019-03-11), p. 34004-
    In: EPL (Europhysics Letters), IOP Publishing, Vol. 125, No. 3 ( 2019-03-11), p. 34004-
    Type of Medium: Online Resource
    ISSN: 1286-4854
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2019
    detail.hit.zdb_id: 1465366-7
    detail.hit.zdb_id: 165776-8
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  • 2
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2017
    In:  Proceedings of the National Academy of Sciences Vol. 114, No. 13 ( 2017-03-28), p. 3340-3345
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 114, No. 13 ( 2017-03-28), p. 3340-3345
    Abstract: Land and sea surface temperatures, precipitation, and storm tracks in North America and the North Pacific are controlled to a large degree by atmospheric variability associated with the Pacific North American (PNA) pattern. The modern instrumental record indicates a trend toward a positive PNA phase in recent decades, which has led to accelerated warming and snowpack decline in northwestern North America. The brevity of the instrumental record, however, limits our understanding of long-term PNA variability and its directional or cyclic patterns. Here we develop a 937-y-long reconstruction of the winter PNA based on a network of annually resolved tree-ring proxy records across North America. The reconstruction is consistent with previous regional records in suggesting that the recent persistent positive PNA pattern is unprecedented over the past millennium, but documents patterns of decadal-scale variability that contrast with previous reconstructions. Our reconstruction shows that PNA has been strongly and consistently correlated with sea surface temperature variation, solar irradiance, and volcanic forcing over the period of record, and played a significant role in translating these forcings into decadal-to-multidecadal hydroclimate variability over North America. Climate model ensembles show limited power to predict multidecadal variation in PNA over the period of our record, raising questions about their potential to project future hydroclimatic change modulated by this circulation pattern.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2015
    In:  Proceedings of the National Academy of Sciences Vol. 112, No. 45 ( 2015-11-10), p. 13988-13993
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 112, No. 45 ( 2015-11-10), p. 13988-13993
    Abstract: Dynamic regulation of chromatin structure is required to modulate the transcription of genes in eukaryotes. However, the factors that contribute to the plasticity of heterochromatin structure are elusive. Here, we report that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment in Drosophila chromosomes. Notably, loss of CDK12 induces the ectopic accumulation of heterochromatin protein 1 (HP1) on euchromatic arms, with a prominent enrichment on the X chromosome. Furthermore, ChIP and sequencing analysis reveals that the heterochromatin enrichment on the X chromosome mainly occurs within long genes involved in neuronal functions. Consequently, heterochromatin enrichment reduces the transcription of neuronal genes in the adult brain and results in a defect in Drosophila courtship learning. Taken together, these results define a previously unidentified role of CDK12 in controlling the epigenetic transition between euchromatin and heterochromatin and suggest a chromatin regulatory mechanism in neuronal behaviors.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2015
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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