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  • 1
    Online Resource
    Online Resource
    Genome of Rhodnius prolixus , an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection
    Proceedings of the National Academy of Sciences ; 2015
    In:  Proceedings of the National Academy of Sciences Vol. 112, No. 48 ( 2015-12), p. 14936-14941
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 112, No. 48 ( 2015-12), p. 14936-14941
    Abstract: Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed, R. prolixus putatively lacks key components of the IMD pathway, suggesting a reorganization of the canonical immune signaling network. Although both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruzi , the causal agent of Chagas disease, implying the existence of evasion or tolerance mechanisms. R . prolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only two proteins, one of which is a selenocysteine-based glutathione peroxidase, the first found in insects. The genome contained actively transcribed, horizontally transferred genes from Wolbachia sp., which showed evidence of codon use evolution toward the insect use pattern. Comparative protein analyses revealed many lineage-specific expansions and putative gene absences in R . prolixus , including tandem expansions of genes related to chemoreception, feeding, and digestion that possibly contributed to the evolution of a blood-feeding lifestyle. The genome assembly and these associated analyses provide critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1506226112
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2015
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    SSG: 11
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Estudo sobre um parâmetro de tarefa e um parâmetro amostral para experimentos com julgamentos de aceitabilidade temporalizados
    Faculdade de Letras da UFMG ; 2015
    In:  Revista de Estudos da Linguagem Vol. 23, No. 1 ( 2015-05-22)
    Details
    In: Revista de Estudos da Linguagem, Faculdade de Letras da UFMG, Vol. 23, No. 1 ( 2015-05-22)
    Type of Medium: Online Resource
    ISSN: 2237-2083 , 0104-0588
    URL: Article
    DOI: 10.17851/2237-2083.23.1.211-244
    RVK:
    IA 1000
    Language: Unknown
    Publisher: Faculdade de Letras da UFMG
    Publication Date: 2015
    detail.hit.zdb_id: 2579650-1
    SSG: 7,11
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  • 3
    Online Resource
    Online Resource
    Violence and Latin‐American preadolescents: A study of social brain function and cortisol levels
    Wiley ; 2019
    In:  Developmental Science Vol. 22, No. 5 ( 2019-09)
    Details
    In: Developmental Science, Wiley, Vol. 22, No. 5 ( 2019-09)
    Abstract: The present study investigated exposure to violence and its association with brain function and hair cortisol concentrations in Latin‐American preadolescents. Self‐reported victimization scores ( JVQ ‐R2), brain imaging ( fMRI ) indices for a social cognition task (the ‘eyes test’), and hair cortisol concentrations were investigated, for the first time, in this population. The eyes test is based on two conditions: attributing mental state or sex to pictures of pairs of eyes (Baron‐Cohen, Wheelwright, Hill, Raste, & Plumb, 2001). The results showed an association among higher victimization scores and (a) less activation of posterior temporoparietal right‐hemisphere areas, in the mental state condition only (including right temporal sulcus and fusiform gyrus); (b) higher functional connectivity indices for the Amygdala and Right Fusiform Gyrus ( RFFG ) pair of brain regions, also in the mental state condition only; (c) higher hair cortisol concentrations. The results suggest more exposure to violence is associated with significant differences in brain function and connectivity. A putative mechanism of less activation in posterior right‐hemisphere regions and of synchronized Amygdala: RFFG time series was identified in the mental state condition only. The results also suggest measurable effects of exposure to violence in hair cortisol concentrations, which contribute to the reliability of self‐reported scores by young adolescents. The findings are discussed in light of the effects of exposure to violence on brain function and on social‐cognitive development in the adolescent brain. A video abstract of this article can be viewed at https://www.youtube.com/watch?v=qHcXq7Y9PBk
    Type of Medium: Online Resource
    ISSN: 1363-755X , 1467-7687
    URL: Issue
    URL: Article
    DOI: 10.1111/desc.v22.5
    DOI: 10.1111/desc.12799
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2023952-X
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds
    Proceedings of the National Academy of Sciences ; 2017
    In:  Proceedings of the National Academy of Sciences Vol. 114, No. 20 ( 2017-05-16), p. 5219-5224
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 114, No. 20 ( 2017-05-16), p. 5219-5224
    Abstract: Yellow, orange, and red coloration is a fundamental aspect of avian diversity and serves as an important signal in mate choice and aggressive interactions. This coloration is often produced through the deposition of diet-derived carotenoid pigments, yet the mechanisms of carotenoid uptake and transport are not well-understood. The white recessive breed of the common canary ( Serinus canaria ), which carries an autosomal recessive mutation that renders its plumage pure white, provides a unique opportunity to investigate mechanisms of carotenoid coloration. We carried out detailed genomic and biochemical analyses comparing the white recessive with yellow and red breeds of canaries. Biochemical analysis revealed that carotenoids are absent or at very low concentrations in feathers and several tissues of white recessive canaries, consistent with a genetic defect in carotenoid uptake. Using a combination of genetic mapping approaches, we show that the white recessive allele is due to a splice donor site mutation in the scavenger receptor B1 ( SCARB1 ; also known as SR-B1 ) gene. This mutation results in abnormal splicing, with the most abundant transcript lacking exon 4. Through functional assays, we further demonstrate that wild-type SCARB1 promotes cellular uptake of carotenoids but that this function is lost in the predominant mutant isoform in white recessive canaries. Our results indicate that SCARB1 is an essential mediator of the expression of carotenoid-based coloration in birds, and suggest a potential link between visual displays and lipid metabolism.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1700751114
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    A hipercontemporaneidade ensanguentada em Ana Paula Maia
    EDIPUCRS ; 2016
    In:  Letras de Hoje Vol. 51, No. 4 ( 2016-12-31), p. 458-
    Details
    In: Letras de Hoje, EDIPUCRS, Vol. 51, No. 4 ( 2016-12-31), p. 458-
    Abstract: A trilogia de Ana Paula Maia, composta por Entre rinhas de cachorros e porcos abatidos, O trabalho sujo dos outros e Carvão animal, descreve cruelmente um grupo de personagens, situados num espaço caracterizado pela subalternidade, humilhação e exclusão social. Através de uma escritura pulp, Ana Paula Maia apresenta uma série de imagens abjetas que tematizam uma polpa de sangue, bichos, violência e esgoto. Alijados do status quo, esses habitantes dos subterrâneos da nossa sociedade, enquanto seres-refugo, desperdiçam as suas vidas fazendo o trabalho sujo para-os-outros. Brutalizadas e coisificadas, essas identidades marginais divertem-se pendurando porcos em ganchos ou contemplando os cães dilacerando-se. Esses homens-de-rinha esperam, sob um calor sufocante do subúrbio, a parte carnosa do real que está urdida sob a égide do resto mutilado do cotidiano: os pedaços dos corpos, dos porcos, dos cães, das esperanças.********************************************************************Bloodstained hyper contemporaneity in Ana Paula MaiaAbstract: The trilogy of Ana Paula Maia, composed of Entre rinhas de cachorros e porcos abatidos, O trabalho sujo dos outros and Carvão animal describes a group of characters set in a space characterized by subordination, humiliation and social exclusion. Through pulp writing, Ana Paula Maia presents a series of abject images whose theme a pulp of blood, animals, violence and sewage. Priced out of the status quo, these inhabitants of the society underground, living as scrap, waste their lives doing the dirty work for others. Brutalized and objectified, these marginal identities have fun hanging pigs in hooks or contemplating dogs tearing each other up. These men – of – baiting expect, under a sweltering suburb, the fleshy part of real that is woven under the aegis of mangled rest of the everyday: the pieces of bodies, pigs, dogs, hopes.Keywords: Contemporary literature; Hyper contemporaneity; Pulp fiction; Identity
    Type of Medium: Online Resource
    ISSN: 1984-7726 , 0101-3335
    URL: Issue
    URL: Article
    DOI: 10.15448/1984-7726.2016.4
    DOI: 10.15448/1984-7726.2016.4.26163
    Language: Unknown
    Publisher: EDIPUCRS
    Publication Date: 2016
    detail.hit.zdb_id: 2421432-2
    SSG: 7,11
    SSG: 7,34
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  • 6
    Online Resource
    Online Resource
    Speech Recognition of Cochlear Implant Users Inside a Noisy Helicopter Environment
    S. Karger AG ; 2019
    In:  Audiology and Neurotology Vol. 24, No. 1 ( 2019), p. 32-37
    Details
    In: Audiology and Neurotology, S. Karger AG, Vol. 24, No. 1 ( 2019), p. 32-37
    Abstract: In this study, we tested whether the speech recognition, through radio communications, of cochlear implant (CI) users inside a noisy helicopter cockpit is adequate for safe flight. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 Speech recognition tests (sentences, numbers and disyllables) through a very-high-frequency radio were administered to 12 CI users in a soundproof booth, inside a helicopter with the engine turned off and turned on. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In quiet environments, radio communications were impacted only for disyllable intelligibility, but in noisy situations, all tests were affected. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 CI subjects did not achieve the auditory levels recommended by the International Civil Aviation Organization.
    Type of Medium: Online Resource
    ISSN: 1420-3030 , 1421-9700
    URL: Article
    DOI: 10.1159/000497031
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1481979-X
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