In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 144, No. 3_Supplement ( 2018-09-01), p. 1699-1699
Abstract:
The current treatment standard for deep vein thrombosis (DVT) is anticoagulation therapy, which does little to address long term morbidity compared to clot removal approaches. High intensity ultrasound can resolve clots by generating bubble clouds that erode thrombi. However, lack of appropriate treatment monitoring is a limiting factor in its widespread adoption. Passive cavitation imaging is capable of high frame rate, volumetric imaging, the combination of which has been shown to be important for monitoring the onset and development of bubble clouds inducing clot erosion (Acconcia et al. 2017). The results from our previous work motivated development of a device tailored to DVT with a relevant geometry (e.g., semi-cylindrical). Transmit simulations for such a device were conducted in a human thigh model (Smirnov and Hynynen 2017) with a design based on the modular transducer technology developed in our lab (Ellens et al. 2015). Here, we examine the integration of a sparse, randomly distributed receiver array within a semi-cylindrical arrangement of transmit modules for acoustic-based monitoring. Using a multi-layered propagation model, cavitation sources were localized to the femoral vessel, the accuracy of which depended on the inclusion of phase corrections. The receiver size was shown to be an important consideration with implicit trade-offs between directivity and channel SNR. Volumetric rates of ~1 MHz should be achievable with a modest number of receivers (128) in the presence of experimentally derived noise conditions.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2018
detail.hit.zdb_id:
1461063-2
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