In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 6 ( 2001-03-13), p. 3346-3351
Abstract:
The tumor suppressor gene FHIT spans a common
fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a
large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using
adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit +/− knockout mice, that are prone to
tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not
only in treatment of early stages of cancer, but also in prevention of human cancer.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.061020098
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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