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  • 1
    Online Resource
    Online Resource
    SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry
    Proceedings of the National Academy of Sciences ; 2022
    In:  Proceedings of the National Academy of Sciences Vol. 119, No. 4 ( 2022-01-25)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 4 ( 2022-01-25)
    Abstract: After binding to its cell surface receptor angiotensin converting enzyme 2 (ACE2), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell through directly fusing with plasma membrane (cell surface pathway) or undergoing endocytosis traveling to lysosome/late endosome for membrane fusion (endocytic pathway). However, the endocytic entry regulation by host cell remains elusive. Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein such as sorting nexin 27 (SNX27). In this study, we determined the ACE2-PBM/SNX27-PDZ complex structure, and, through a series of functional analyses, we found SNX27 plays an important role in regulating the homeostasis of ACE2 receptor. More importantly, we demonstrated SNX27, together with retromer complex (the core component of the endosomal protein sorting machinery), prevents ACE2/virus complex from entering lysosome/late endosome, resulting in decreased viral entry in cells where the endocytic pathway dominates. The ACE2/virus retrieval mediated by SNX27–retromer could be considered as a countermeasure against invasion of ACE2 receptor-using SARS coronaviruses.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2117576119
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2022
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    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Knowledge about dyslexia among early literacy teachers in China
    Wiley ; 2020
    In:  Dyslexia Vol. 26, No. 3 ( 2020-08), p. 247-265
    Details
    In: Dyslexia, Wiley, Vol. 26, No. 3 ( 2020-08), p. 247-265
    Abstract: This study examined knowledge about dyslexia among Chinese‐speaking early literacy teachers in Mainland China. A total of 516 teachers, including 203 kindergarten teachers from developed regions (KDRs), 166 primary school teachers from developed regions (PDRs), and 147 primary school teachers from less developed regions (PLDRs), completed a survey measuring knowledge about dyslexia in three domains: general information, symptoms/diagnosis, and treatment. PLDRs scored significantly lower on the total scale and each of the subscales than KDRs and PDRs, with the latter two not significantly different from each other. The percentages of misunderstandings and lack of knowledge (“do not know” response) were higher for PLDRs than for KDRs or PDRs. In general, compared with alphabetic language‐speaking teachers in developed countries reported in previous studies, Chinese teachers showed less knowledge about dyslexia but similar misunderstandings. Prior exposure to children with dyslexia explained significant variance in Chinese teachers' knowledge about dyslexia, indicating that when specialized training is not available, learning from practice is a major source of knowledge about dyslexia. Findings of this study point to the universal need of providing explicit training on dyslexia for teachers, particularly in less developed regions where teacher knowledge is poorer.
    Type of Medium: Online Resource
    ISSN: 1076-9242 , 1099-0909
    URL: Issue
    URL: Article
    DOI: 10.1002/dys.v26.3
    DOI: 10.1002/dys.1635
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1501502-6
    SSG: 7,11
    SSG: 5,3
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  • 3
    Online Resource
    Online Resource
    Data envelopment analysis classification machine
    Elsevier BV ; 2011
    In:  Information Sciences Vol. 181, No. 22 ( 2011-11), p. 5029-5041
    Details
    In: Information Sciences, Elsevier BV, Vol. 181, No. 22 ( 2011-11), p. 5029-5041
    Type of Medium: Online Resource
    ISSN: 0020-0255
    URL: Article
    DOI: 10.1016/j.ins.2011.07.011
    RVK:
    SA 5420
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 218760-7
    detail.hit.zdb_id: 1478990-5
    SSG: 24,1
    SSG: 7,11
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  • 4
    Online Resource
    Online Resource
    Supervised classification of share price trends
    Elsevier BV ; 2008
    In:  Information Sciences Vol. 178, No. 20 ( 2008-10), p. 3943-3956
    Details
    In: Information Sciences, Elsevier BV, Vol. 178, No. 20 ( 2008-10), p. 3943-3956
    Type of Medium: Online Resource
    ISSN: 0020-0255
    URL: Article
    DOI: 10.1016/j.ins.2008.06.002
    RVK:
    SA 5420
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2008
    detail.hit.zdb_id: 218760-7
    detail.hit.zdb_id: 1478990-5
    SSG: 24,1
    SSG: 7,11
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  • 5
    Online Resource
    Online Resource
    Text-Independent Phoneme Segmentation Combining EGG and Speech Data
    Institute of Electrical and Electronics Engineers (IEEE) ; 2016
    In:  IEEE/ACM Transactions on Audio, Speech, and Language Processing Vol. 24, No. 6 ( 2016-6), p. 1029-1037
    Details
    In: IEEE/ACM Transactions on Audio, Speech, and Language Processing, Institute of Electrical and Electronics Engineers (IEEE), Vol. 24, No. 6 ( 2016-6), p. 1029-1037
    Type of Medium: Online Resource
    ISSN: 2329-9290 , 2329-9304
    URL: Article
    DOI: 10.1109/TASLP.2016.2533865
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016
    detail.hit.zdb_id: 2751224-1
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  • 6
    Online Resource
    Online Resource
    Ontogenetic development of mechanosensory ability of a pomacentrid coral fish, the red saddleback clownfish ( Amphiprion   ephippium )
    Acoustical Society of America (ASA) ; 2002
    In:  The Journal of the Acoustical Society of America Vol. 112, No. 5_Supplement ( 2002-11-01), p. 2204-2204
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 112, No. 5_Supplement ( 2002-11-01), p. 2204-2204
    Abstract: Recent work on the settlement of coral reef fish suggests that ambient sound could be used as a cue for navigation by the pelagic larvas of reef fishes. Coral reef fish larvas made directional movements toward sound stimulus indicating they are capable of detecting and localizing sound. These findings suggest that some degrees of hearing abilities must have developed prior to settlement. We used embryos and newly hatched larvas of a clown fish (Amphiprion ephippium) to investigate the ontogenetic development of the auditory function of this fish. The heart beat rates of embryos and newly hatched larvas (up to 7 days after hatching) in response to various frequencies of sound were measured to indicate their reaction to mechanosensory stimuli. The auditory brainstem response (ABR) recording protocol was used to measure acoustically evoked potentials of Day-8 to Day-36 larvas. Preliminary findings indicate that both the embryos’ and larvas reaction to sound stimuli improved (both frequency range and sound pressure level) throughout the development. The electrophysiological observations on embryos and larvas of Amphiprion ephippium provide evidence to support the hypothesis that acoustic stimuli could be used as a cue for coral reef larval fish migration use. [Work supported by NIH, NOHR, IMLS, NERC, AIMS.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4778672
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2002
    detail.hit.zdb_id: 1461063-2
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  • 7
    Online Resource
    Online Resource
    FFA-1, a Protein That Promotes the Formation of Replication Centers Within Nuclei
    American Association for the Advancement of Science (AAAS) ; 1995
    In:  Science Vol. 269, No. 5232 ( 1995-09-29), p. 1883-1885
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 269, No. 5232 ( 1995-09-29), p. 1883-1885
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.7569932
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 1995
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 8
    Online Resource
    Online Resource
    A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition
    Society for Neuroscience ; 2023
    In:  The Journal of Neuroscience Vol. 43, No. 13 ( 2023-03-29), p. 2305-2325
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 43, No. 13 ( 2023-03-29), p. 2305-2325
    Abstract: Cholecystokinin (CCK) enables excitatory circuit long-term potentiation (LTP). Here, we investigated its involvement in the enhancement of inhibitory synapses. Activation of GABA neurons suppressed neuronal responses in the neocortex to a forthcoming auditory stimulus in mice of both sexes. High-frequency laser stimulation (HFLS) of GABAergic neurons potentiated this suppression. HFLS of CCK interneurons could induce the LTP of their inhibition toward pyramidal neurons. This potentiation was abolished in CCK knock-out mice but intact in mice with both CCK1R and 2R knockout of both sexes. Next, we combined bioinformatics analysis, multiple unbiased cell-based assays, and histology examinations to identify a novel CCK receptor, GPR173. We propose GPR173 as CCK3R, which mediates the relationship between cortical CCK interneuron signaling and inhibitory LTP in the mice of either sex. Thus, GPR173 might represent a promising therapeutic target for brain disorders related to excitation and inhibition imbalance in the cortex. SIGNIFICANCE STATEMENT CCK, the most abundant and widely distributed neuropeptide in the CNS, colocalizes with many neurotransmitters and modulators. GABA is one of the important inhibitory neurotransmitters, and much evidence shows that CCK may be involved in modulating GABA signaling in many brain areas. However, the role of CCK-GABA neurons in the cortical microcircuits is still unclear. We identified a novel CCK receptor, GPR173, localized in the CCK-GABA synapses and mediated the enhancement of the GABA inhibition effect, which might represent a promising therapeutic target for brain disorders related to excitation and inhibition imbalance in the cortex.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    DOI: 10.1523/JNEUROSCI.2035-22.2023
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2023
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Multiscale co-clustering for tensor data based on canonical polyadic decomposition and slice-wise factorization
    Elsevier BV ; 2019
    In:  Information Sciences Vol. 503 ( 2019-11), p. 72-91
    Details
    In: Information Sciences, Elsevier BV, Vol. 503 ( 2019-11), p. 72-91
    Type of Medium: Online Resource
    ISSN: 0020-0255
    URL: Article
    DOI: 10.1016/j.ins.2019.06.044
    RVK:
    SA 5420
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
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    detail.hit.zdb_id: 1478990-5
    SSG: 24,1
    SSG: 7,11
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  • 10
    Online Resource
    Online Resource
    Extreme weather events recorded by daily to hourly resolution biogeochemical proxies of marine giant clam shells
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 13 ( 2020-03-31), p. 7038-7043
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 13 ( 2020-03-31), p. 7038-7043
    Abstract: Paleoclimate research has built a framework for Earth’s climate changes over the past 65 million years or even longer. However, our knowledge of weather-timescale extreme events (WEEs, also named paleoweather), which usually occur over several days or hours, under different climate regimes is almost blank because current paleoclimatic records rarely provide information with temporal resolution shorter than monthly scale. Here we show that giant clam shells ( Tridacna spp.) from the tropical western Pacific have clear daily growth bands, and several 2-y-long (from January 29, 2012 to December 9, 2013) daily to hourly resolution biological and geochemical records, including daily growth rate, hourly elements/Ca ratios, and fluorescence intensity, were obtained. We found that the pulsed changes of these ultra-high-resolution proxy records clearly matched with the typical instrumental WEEs, for example, tropical cyclones during the summer−autumn and cold surges during the winter. When a tropical cyclone passes through or approaches the sampling site, the growth rate of Tridacna shell decreases abruptly due to the bad weather. Meanwhile, enhanced vertical mixing brings nutrient-enriched subsurface water to the surface, resulting in a high Fe/Ca ratio and strong fluorescence intensity (induced by phytoplankton bloom) in the shell. Our results demonstrate that Tridacna shell has the potential to be used as an ultra-high-resolution archive for paleoweather reconstructions. The fossil shells living in different geological times can be built as a Geological Weather Station network to lengthen the modern instrumental data and investigate the WEEs under various climate conditions.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1916784117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2020
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    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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