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  • 1
    Online Resource
    Online Resource
    The effect of speech material on the band importance function for Mandarin Chinese
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 146, No. 1 ( 2019-07-01), p. 445-457
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 146, No. 1 ( 2019-07-01), p. 445-457
    Abstract: Speech material influences the relative contributions of different frequency regions to intelligibility for English. In the current study, whether a similar effect of speech material is present for Mandarin Chinese was investigated. Speech recognition was measured using three speech materials in Mandarin, including disyllabic words, nonsense sentences, and meaningful sentences. These materials differed from one another in terms of the amount of contextual information and word frequency. The band importance function (BIF), as defined under the Speech Intelligibility Index (SII) framework, was used to quantify the contributions across frequency regions. The BIFs for the three speech materials were estimated from 16 adults who were native speakers of Mandarin. A Bayesian adaptive procedure was used to efficiently estimate the octave-frequency BIFs for the three materials for each listener. As the amount of contextual information increased, low-frequency bands (e.g., 250 and 500 Hz) became more important for speech recognition, consistent with English. The BIF was flatter for Mandarin than for comparable English speech materials. Introducing the language- and material-specific BIFs to the SII model led to improved predictions of Mandarin speech-recognition performance. Results suggested the necessity of developing material-specific BIFs for Mandarin.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5116691
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    P31 comet , a member of the synaptonemal complex, participates in meiotic DSB formation in rice
    Proceedings of the National Academy of Sciences ; 2016
    In:  Proceedings of the National Academy of Sciences Vol. 113, No. 38 ( 2016-09-20), p. 10577-10582
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 113, No. 38 ( 2016-09-20), p. 10577-10582
    Abstract: The human mitotic arrest-deficient 2 (Mad2) binding protein p31 comet participates in the spindle checkpoint and coordinates cell cycle events in mitosis although its function in meiosis remains unknown in all organisms. Here, we reveal P31 comet as a synaptonemal complex (SC) protein in rice ( Oryza sativa L.). In p31 comet , homologous pairing and synapsis are eliminated, leading to the homologous nondisjunction and complete sterility. The failure in loading of histone H2AX phosphorylation (γH2AX) in p31 comet , together with the suppressed chromosome fragmentation in rice completion of meiotic recombination 1 ( com1 ) p31 comet and radiation sensitive 51c ( rad51c ) p31 comet double mutants, indicates that P31 comet plays an essential role in double-strand break (DSB) formation. Interestingly, the dynamic colocalization pattern between P31 comet and ZEP1 (a transverse filament protein of SC) by immunostaining, as well as the interaction between P31 comet and CENTRAL REGION COMPONENT 1 (CRC1) in yeast two-hybrid assays, suggests possible involvement of P31 comet in SC installation. Together, these data indicate that P31 comet plays a key role in DSB formation and SC installation, mainly through its cooperation with CRC1.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1607334113
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2016
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    HEIP1 regulates crossover formation during meiosis in rice
    Proceedings of the National Academy of Sciences ; 2018
    In:  Proceedings of the National Academy of Sciences Vol. 115, No. 42 ( 2018-10-16), p. 10810-10815
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 115, No. 42 ( 2018-10-16), p. 10810-10815
    Abstract: During meiosis, the number of double-strand breaks (DSBs) far exceeds the final number of crossovers (COs). Therefore, to identify proteins involved in determining which of these DSBs repaired into COs is critical in understanding the mechanism of CO control. Across species, HEI10-related proteins play important roles in CO formation. Here, through screening for HEI10-interacting proteins via a yeast two-hybrid system, we identify a CO protein HEI10 Interaction Protein 1 (HEIP1) in rice. HEIP1 colocalizes with HEI10 in a dynamic fashion along the meiotic chromosomes and specially localizes onto crossover sites from late pachytene to diplotene. Between these two proteins, HEI10 is required for the loading of HEIP1, but not vice versa. Moreover, mutations of the HEIP1 gene cause the severe reduction of chiasma frequency, whereas early homologous recombination processes are not disturbed and synapsis proceeds normally. HEIP1 interacts directly with ZIP4 and MSH5. In addition, the loading of HEIP1 depends on ZIP4, but not on MER3, MSH4, or MSH5. Together, our results suggest that HEIP1 may be a member of the ZMM group and acts as a key element regulating CO formation.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1807871115
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2018
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
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