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  • 1
    Online Resource
    Online Resource
    Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
    Springer Science and Business Media LLC ; 2019
    In:  Nature Neuroscience Vol. 22, No. 8 ( 2019-8), p. 1223-1234
    Details
    In: Nature Neuroscience, Springer Science and Business Media LLC, Vol. 22, No. 8 ( 2019-8), p. 1223-1234
    Type of Medium: Online Resource
    ISSN: 1097-6256 , 1546-1726
    URL: Article
    DOI: 10.1038/s41593-019-0445-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 1420596-8
    detail.hit.zdb_id: 1494955-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation
    Proceedings of the National Academy of Sciences ; 2023
    In:  Proceedings of the National Academy of Sciences Vol. 120, No. 51 ( 2023-12-19)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 51 ( 2023-12-19)
    Abstract: Adipose tissue macrophages (ATM) are key players in the development of obesity and associated metabolic inflammation which contributes to systemic metabolic dysfunction. We here found that fibroblast activation protein α (FAP), a well-known marker of cancer-associated fibroblast, is selectively expressed in murine and human ATM among adipose tissue-infiltrating leukocytes. Macrophage FAP deficiency protects mice against diet-induced obesity and proinflammatory macrophage infiltration in obese adipose tissues, thereby alleviating hepatic steatosis and insulin resistance. Mechanistically, FAP specifically mediates monocyte chemokine protein CCL8 expression by ATM, which is further upregulated upon high-fat-diet (HFD) feeding, contributing to the recruitment of monocyte-derived proinflammatory macrophages with no effect on their classical inflammatory activation. CCL8 overexpression restores HFD-induced metabolic phenotypes in the absence of FAP. Moreover, macrophage FAP deficiency enhances energy expenditure and oxygen consumption preceding differential body weight after HFD feeding. Such enhanced energy expenditure is associated with increased levels of norepinephrine (NE) and lipolysis in white adipose tissues, likely due to decreased expression of monoamine oxidase, a NE degradation enzyme, by Fap −/− ATM. Collectively, our study identifies FAP as a previously unrecognized regulator of ATM function contributing to diet-induced obesity and metabolic inflammation and suggests FAP as a potential immunotherapeutic target against metabolic disorders.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2303075120
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    The effect of voice cuing on releasing Chinese speech from informational masking
    Elsevier BV ; 2007
    In:  Speech Communication Vol. 49, No. 12 ( 2007-12), p. 892-904
    Details
    In: Speech Communication, Elsevier BV, Vol. 49, No. 12 ( 2007-12), p. 892-904
    Type of Medium: Online Resource
    ISSN: 0167-6393
    URL: Article
    DOI: 10.1016/j.specom.2007.05.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2007
    detail.hit.zdb_id: 1460279-9
    SSG: 7,11
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  • 4
    Online Resource
    Online Resource
    Attempt to Predict Temporal Modulation Transfer Function by Amplitude Modulation Following Responses
    Wissenschaftliche Verlagsgesellschaft mbH ; 2018
    In:  Acta Acustica united with Acustica Vol. 104, No. 5 ( 2018-09-01), p. 821-824
    Details
    In: Acta Acustica united with Acustica, Wissenschaftliche Verlagsgesellschaft mbH, Vol. 104, No. 5 ( 2018-09-01), p. 821-824
    Type of Medium: Online Resource
    ISSN: 1610-1928
    URL: Article
    DOI: 10.3813/AAA.919237
    Language: English
    Publisher: Wissenschaftliche Verlagsgesellschaft mbH
    Publication Date: 2018
    detail.hit.zdb_id: 119-3
    SSG: 7,11
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  • 5
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    Online Resource
    Auditory priming releases Chinese speech from informational masking
    Acoustical Society of America (ASA) ; 2006
    In:  The Journal of the Acoustical Society of America Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3341-3342
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3341-3342
    Abstract: Before an English speech sentence is presented, hearing or reading the sentence without the last key word improves recognition of the last key word if the full-length speech sentence is presented under speech masking but not under noise masking. This phenomenon suggests a content priming effect on releasing speech from informational masking. To determine whether the priming effect extends to tonal Chinese speech, and, in particular, whether it can be induced by the target talkers voice, in the present study, listeners were presented with either same-voice/different-sentence primes or same-voice/same-sentence primes before hearing the target sentence in either two-talker-speech masking or noise masking. Under speech masking, each of the two prime types significantly improved recognition of the last key word in the full-length target sentence, but the content priming is stronger than the voice priming. Under noise masking, same-voice/same-sentence primes had a weak but significant priming effect, but same-voice/different-sentence primes had only a negligible priming effect. These results suggest that both content and voice cues can be used by listeners to release Chinese speech from informational masking, but only content cues are useful for releasing Chinese speech from energetic masking. [Work supported by China NSF and Canadian IHR.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4781344
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2006
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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  • 6
    Online Resource
    Online Resource
    Both prime length and prime position affect the spatial release of nonsense speech from informational masking
    Acoustical Society of America (ASA) ; 2008
    In:  The Journal of the Acoustical Society of America Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3295-3295
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3295-3295
    Abstract: When masking speech is present, pre-presentation of early part of nonsense target speech improves recognition of the rest of target speech, indicating a content and/or voice priming effect (Freyman et al., 2004; Yang et al., 2007). Here, we examined both the prime-length effect and the prime-position effect on recognition of nonsense target speech with twelve syllables and three keywords. Target speech started 1 sec. after the onset of two-talker masking speech. The results show that a longer prime with 10 syllables (including the 1st and 2nd keywords) significantly improved recognition of the last (3rd) keyword in target speech. However, when the 1st four syllables (including the 1st keyword) were pre-presented, recognition of either the 2nd or 3rd keyword was not improved. Interestingly, when the 2nd four syllables (including the 2nd keyword) were pre-presented, recognition of the 1st but not the 3rd keyword was significantly improved. Thus under speech-on-speech masking conditions, both the prime length and the prime position in the sentence influence the priming effect on recognition of target speech, and listeners contribute more attentional resource to the initial part of target speech. Supported by the National Natural Science Foundation of China.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2933695
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2008
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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  • 7
    Online Resource
    Online Resource
    Topic expression, information saliency and anaphora resolution
    Elsevier BV ; 2009
    In:  Journal of Pragmatics Vol. 41, No. 9 ( 2009-9), p. 1703-1706
    Details
    In: Journal of Pragmatics, Elsevier BV, Vol. 41, No. 9 ( 2009-9), p. 1703-1706
    Type of Medium: Online Resource
    ISSN: 0378-2166
    URL: Article
    DOI: 10.1016/j.pragma.2009.01.006
    RVK:
    EQ 1000
    RVK:
    EQ 2689
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 131841-X
    SSG: 5,1
    SSG: 5,2
    SSG: 7,11
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  • 8
    Online Resource
    Online Resource
    Effect of speech rate on speech-on-speech masking
    Acoustical Society of America (ASA) ; 2008
    In:  The Journal of the Acoustical Society of America Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3713-3713
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3713-3713
    Abstract: Target speech can be better recognized under speech-on-speech masking conditions if certain differences between target and masker (e.g. in loudness, pitch, location) can be used as cues for streaming. This study examined whether the speech rate can be used by listeners as a cue for unmasking target speech. The rate difference between target and masking speech was manipulated by changing the rate of masking speech using the Synchronized Overlap-Add Fixed Synthesis (SOLAFS) algorithm, and consequently, the ratio of target speech to masking speech (the speech rate ratio, SRR) was quantified. Both target and masker speech were Chinese nonsense sentences and they were co-presented with the signal-to-masker ratio of -7 dB. The results show that speech recognition was significantly increased with the SRR increase from 1 to 1.5 or the SRR decreased from 1 to 0.5. Moreover, the unmasking effect of precedence-induced perceived spatial separation on target-speech recognition was increased monotonically with the increase of the SRR from 0.5 to 1.5. These results suggest that the speech rate is one of the factors influencing both energetic masking and informational masking of Chinese speech. [Supported by the NSFC 60435010; 60535030; 60605016; 30670704]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2935152
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2008
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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  • 9
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    Online Resource
    Simulated phase-locking stimulation: An improved signal processing strategy for cochlear implant
    Acoustical Society of America (ASA) ; 2005
    In:  The Journal of the Acoustical Society of America Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2397-2397
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2397-2397
    Abstract: Electrical stimulation of the auditory pathway produces different patterns of neural activity than those acoustically elicited. Traditional signal-processing strategies for cochlear implant usually do not utilize phase information contained in sound waves. Here, to evaluate potential advantages of introducing phase information to cochlear implant devices, a new signal processing method, so called simulated phase-locking stimulation (SPLS), was developed. To convey phase information of sound signals to the auditory nerve, electrical stimulation pulses were delivered at the zero-crossing time of sine waves of frequency bands after band-pass filtering and envelope extraction. The advantages of the SPLS method over the method of Continuous Interleaved Sampling (CIS+) were demonstrated by both objective evaluations, such as the spectro-temporal modulation index (STMI), and subjective evaluations, such as recognition of processed Chinese speech by normal hearing listeners under either noise (energetic) masking or speech (informational) masking conditions. The results suggest that the SPLS method is able to improve the function of cochlear devices by extracting and transferring fine-structure signals, which are important for cochlear-implant listeners to perceive tonal speech and music.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4785964
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2005
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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  • 10
    Online Resource
    Online Resource
    The fading of auditory memory
    Acoustical Society of America (ASA) ; 2005
    In:  The Journal of the Acoustical Society of America Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2599-2600
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2599-2600
    Abstract: Due to auditory memory, the auditory system is capable of maintaining a detailed representation of arbitrary waveforms for a period of time, so that a broadband noise and its delayed copies can be perceptually fused. This auditory memory would be critical for perceptually grouping correlated sounds and segregating uncorrelated sounds in noisy, reverberant environments. Its fading process over time was investigated in the present study at the behavioral level, using a break in correlation (BIC, a drop of inter-sound correlation from 1.00 to 0 and then return to 1.00) between two correlated broadband noises. The results show that with the rise of inter-sound delay from 2 to 10 ms under either headphone-stimulation or loudspeaker-stimulation conditions, the shortest BIC duration necessary for listeners to correctly detect the occurrence of the BIC increased rapidly. This elevation in the duration threshold was faster under the headphone-stimulation condition than the loudspeaker-stimulation condition. Also, the listeners reaction time in response to the BIC but not that to a comparable silent gap elongated quickly with the increase in the inter-sound delay from 1 to 8 ms. Thus the auditory memory of fine structures fades rapidly after the sound waves are received. [Work supported by MSTC and NSERCC.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4777579
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2005
    detail.hit.zdb_id: 1461063-2
    detail.hit.zdb_id: 219231-7
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