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  • 1
    Online Resource
    Online Resource
    Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity
    American Association for the Advancement of Science (AAAS) ; 2005
    In:  Science Vol. 307, No. 5708 ( 2005-01-21), p. 418-420
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 307, No. 5708 ( 2005-01-21), p. 418-420
    Abstract: In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1108177
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2005
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    Meditation-Specific Prefrontal Cortical Activation during Acem Meditation: An FMRI Study
    SAGE Publications ; 2010
    In:  Perceptual and Motor Skills Vol. 111, No. 1 ( 2010-08), p. 291-306
    Details
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 111, No. 1 ( 2010-08), p. 291-306
    Abstract: Some of the most popular meditation practices emphasize a relaxed focus of attention in which thoughts, images, sensations, and emotions may emerge and pass freely without actively controlling or pursuing them. Several recent studies show that meditation activates frontal brain areas associated with attention focusing and physical relaxation. The objective of the present study was to assess whether brain activation during relaxed focusing on a meditation sound could be distinguished from similar, concentrative control tasks. Brain activation was measured with functional magnetic resonance imaging (fMRI) in experienced practitioners of Acem meditation. Bilateral areas of the inferior frontal gyrus (BA47) were significantly more activated during repetition of a meditation sound than during concentrative meditation-like cognitive tasks. Meditation-specific brain activation did not habituate over time, but increased in strength with continuous meditation bouts. These observations suggest that meditation with a relaxed focus of attention may activate distinct areas of the prefrontal cortex, with implications for the understanding of neurobiological correlates of meditation.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    URL: Article
    DOI: 10.2466/02.04.22.PMS.111.4.291-306
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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