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  • 11
    Online Resource
    Online Resource
    The association of SOD and HsCRP with the efficacy of sulforaphane in schizophrenia patients with residual negative symptoms
    Springer Science and Business Media LLC ; 2024
    In:  European Archives of Psychiatry and Clinical Neuroscience Vol. 274, No. 5 ( 2024-08), p. 1083-1092
    Details
    In: European Archives of Psychiatry and Clinical Neuroscience, Springer Science and Business Media LLC, Vol. 274, No. 5 ( 2024-08), p. 1083-1092
    Abstract: Emerging evidence indicates a connection between oxidative stress, immune-inflammatory processes, and the negative symptoms of schizophrenia. In addition to possessing potent antioxidant and anti-inflammatory properties, sulforaphane (SFN) has shown promise in enhancing cognitive function among individuals with schizophrenia. This study aims to investigate the efficacy of combined treatment with SFN in patients with schizophrenia who experience negative symptoms and its effect on the levels of superoxide dismutase (SOD) and the inflammatory marker, high-sensitivity C-reactive protein (HsCRP). Design Forty-five patients with schizophrenia were recruited, who mainly experienced negative symptoms during a stable period. In addition to the original treatments, the patients received SFN tablets at a daily dose of 90 mg for 24 weeks. At baseline, 12 weeks, and 24 weeks, the participants were interviewed and evaluated. The reduction rate of the Positive and Negative Syndrome Scale (PANSS) was used to assess each participant. The side effects scale of Treatment Emergent Symptom Scale (TESS) was applied to assess the adverse reactions. Additionally, the levels of the SOD, HsCRP, and other indicators were examined. Results The study findings revealed a significant decrease in PANSS negative subscale scores ( P   〈  0.001). Furthermore, there was a significant increase in SOD activity and HsCRP levels ( P   〈  0.001 and P   〈  0.05). Notably, the group of participants who exhibited a reduction in PANSS negative subscale scores demonstrated a significant improvement in HsCRP levels ( P   〈  0.05). Conclusions Our study suggests that SFN may potentially serve as a safe adjunctive intervention to improve the negative symptoms of schizophrenia. The potential mechanism by which SFN improves negative symptoms in schizophrenia patients may involve its anti-inflammatory properties, specifically its ability to reduce HsCRP levels. Trial registration ClinicalTrial.gov (ID: NCT03451734).
    Type of Medium: Online Resource
    ISSN: 0940-1334 , 1433-8491
    URL: Article
    DOI: 10.1007/s00406-023-01679-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
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  • 12
    Online Resource
    Online Resource
    The Mediating Role of Coping Style: Associations Between Intimate Partner Violence and Suicide Risks Among Chinese Wives of Men Who Have Sex With Men
    SAGE Publications ; 2021
    In:  Journal of Interpersonal Violence Vol. 36, No. 11-12 ( 2021-06), p. NP6304-NP6322
    Details
    In: Journal of Interpersonal Violence, SAGE Publications, Vol. 36, No. 11-12 ( 2021-06), p. NP6304-NP6322
    Abstract: The wives of men who have sex with men, known as “ Tongqi” in China, have increasingly attracted public attention due to their potential risks of suicide and sexually transmitted infections and HIV. However, few studies have explored the association between intimate partner violence (IPV) and suicide risk or the mediating effect of coping style on these associations among Tongqi in China. To describe these relationships, a cross-sectional online survey was conducted in China from February 2016 to February 2017. A questionnaire, which consisted of the Revised Conflict Tactics Scales, the Simplified Coping Style Questionnaire, the Beck Scale for Suicidal Ideation, and reports of suicide attempts, was completed by 178 Chinese Tongqi. Bootstrap tests were performed to determine the mediating role of coping styles on the association between IPV and suicide risks. The median IPV score was 14 (range: 0-50), with the domain of negotiation ranking highest. The average coping style score was .37±.73; 61.2% of Tongqi have had suicidal ideation, and 11.8% had attempted suicide. IPV was significantly correlated with suicidal ideation ( r s = .19, p 〈 .01) and suicide attempts ( r s = .29, p 〈 .001). Participants with a negative coping style had higher suicidal ideation ( r s = –.39, p 〈 .01) and suicide attempts ( r s = –.22, p 〈 .01). Coping style had a full mediating effect on the association between IPV and suicidal ideation and a partial mediating effect on suicide attempts. Chinese Tongqi experienced high level of IPV and suicide risks. IPV contributed to the suicide risks of Chinese Tongqi, but these associations were mediated by coping style. Therefore, interventions to improve mental health and prevent suicide risks of Chinese Tongqi should focus on helping them develop a positive coping style to achieve the goal of Healthy China in 2030.
    Type of Medium: Online Resource
    ISSN: 0886-2605 , 1552-6518
    URL: Article
    DOI: 10.1177/0886260518814264
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 13
    Online Resource
    Online Resource
    The Lateralization of Attentional Functions in Action Video Game Players
    Hogrefe Publishing Group ; 2021
    In:  Experimental Psychology Vol. 68, No. 4 ( 2021-07), p. 198-205
    Details
    In: Experimental Psychology, Hogrefe Publishing Group, Vol. 68, No. 4 ( 2021-07), p. 198-205
    Abstract: Abstract. Action video game players (AVGPs) are proven to be significantly different from non-AVGPs (NAVGPs) in attention, which is proposed to be divided into three functional networks: alerting, orienting, and execution control. However, whether the hemispheric lateralization of attentional functions is influenced by the action video game is unclear. In the present study, we examined the lateralization of the three attentional functions in a group of AVGPs ( n = 33) compared to NAVGPs ( n = 34). The results showed that, relative to NAVGPs, the interactions between orienting and executive control in the left hemispheres of AVGPs were higher than those in the right hemisphere. Moreover, the correlations among the functions are much more sensitive in the left hemisphere. These results suggest significant left lateralization of the attentional functions in AVGPs.
    Type of Medium: Online Resource
    ISSN: 1618-3169 , 2190-5142
    URL: Article
    DOI: 10.1027/1618-3169/a000522
    RVK:
    CL 1000
    Language: English
    Publisher: Hogrefe Publishing Group
    Publication Date: 2021
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  • 14
    Online Resource
    Online Resource
    Delayed elimination in humans after ingestion of colchicine: Two fatal cases of colchicine poisoning
    Wiley ; 2023
    In:  Journal of Forensic Sciences Vol. 68, No. 4 ( 2023-07), p. 1425-1430
    Details
    In: Journal of Forensic Sciences, Wiley, Vol. 68, No. 4 ( 2023-07), p. 1425-1430
    Abstract: Colchicine has been widely used in the treatment of acute gout over the years, but it has a narrow therapeutic index, and overdose can be life threatening. A method using ultra‐high‐performance liquid chromatography–tandem mass spectrometry system was applied in two fatal cases of colchicine poisoning in this study to the determination of colchicine in blood. In case 1, a 19‐year‐old man suffered from depression and ingested 160 colchicine tablets (each 0.5 mg). The concentration of colchicine in his blood samples showed a fluctuating trend and kept above the therapeutic steady‐state concentration for 5 days. In case 2, a 70‐year‐old female patient with a history of gout and chronic colchicine intake ingested five times the usual dose of colchicine (5 mg) and died after 12 days of medical care, with 5 ng/mL of colchicine in her blood sample. Our findings suggest that the delayed elimination and accumulation in humans after colchicine overdose could keep the concentration of colchicine maintaining above the therapeutic steady‐state concentration for many days before dying, probably along with a fluctuating trend.
    Type of Medium: Online Resource
    ISSN: 0022-1198 , 1556-4029
    URL: Issue
    URL: Article
    DOI: 10.1111/jfo.v68.4
    DOI: 10.1111/1556-4029.15298
    RVK:
    XA 53670
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 15
    Online Resource
    Online Resource
    Developments of prolonged exposure in treatment effect of post‐traumatic stress disorder and controlling dropout rate: A meta‐analytic review
    Wiley ; 2020
    In:  Clinical Psychology & Psychotherapy Vol. 27, No. 4 ( 2020-07), p. 449-462
    Details
    In: Clinical Psychology & Psychotherapy, Wiley, Vol. 27, No. 4 ( 2020-07), p. 449-462
    Abstract: Prolonged exposure (PE) has been proved as an efficacious psychological treatment for post‐traumatic stress disorder (PTSD). There are mainly two changed formats of PE: the modified PE (mPE) and the PE combined with drug (PE/d). Symptom reduction following these two PE training formats has been reported in the patients with PTSD. However, very little is focusing on the direct comparison of mPE + PE/d and PE. Therefore, this paper aims to compare the mPE + PE/d with PE on the PTSD treatment effect and the dropout rate directly through the meta‐analysis. Eighteen studies with total sample size of 1,397 met the final inclusion criteria. The results showed that mPE + PE/d had significantly lower posttreatment PTSD severity than control group (relaxation, wait list, etc.). There was no significant difference between mPE + PE/d and PE on the posttreatment, the follow‐up PTSD score, and the posttreatment dropout rate. Compared with PE, lower PTSD symptoms and marginally lower dropout rate following the treatment were observed in the PE/d group. PE/d yielded a significantly larger effect size than mPE when compared with PE on the posttreatment PTSD symptom severity. The significance of the above results would not be changed even if studies causing high heterogeneity were removed. Although PE/d enhanced treatment effect and lowered dropout rate when compared with PE, it was still insufficient to draw the conclusion that formats of adjustments would specifically improve the implementation of PE. Further studies are warranted to develop an easily accomplished and efficacy‐guaranteeing PE programme for PTSD patients.
    Type of Medium: Online Resource
    ISSN: 1063-3995 , 1099-0879
    URL: Issue
    URL: Article
    DOI: 10.1002/cpp.v27.4
    DOI: 10.1002/cpp.2443
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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    SSG: 5,2
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