In:
Oncology, S. Karger AG, Vol. 78, No. 5-6 ( 2010), p. 382-388
Abstract:
〈 i 〉 Objective: 〈 /i 〉 Although signal transducer and activator of transcription 1 (STAT1), a transcription factor, plays a critical role in carcinogenesis and has been implicated as a tumor suppressor, few studies have investigated the associations between polymorphisms of this gene and the risk of cancer development. The aim of this study was to examine whether 〈 i 〉 STAT1 〈 /i 〉 gene polymorphisms are associated with the risk of hepatocellular carcinoma (HCC). 〈 i 〉 Methods: 〈 /i 〉 Ten single nucleotide polymorphisms in the 〈 i 〉 STAT1 〈 /i 〉 gene were genotyped by TaqMan assays in 469 HCC cases and 558 age-, sex- and HBsAg-matched controls in a Chinese population. 〈 i 〉 Results: 〈 /i 〉 Minor allele homozygous genotypes at rs867637 (9,046 bp 3′ of STP A 〉 G), rs3771300 (IVS24–153T 〉 G), and rs2280235 (IVS20–103G 〉 A), compared with their homozygote genotypes of common alleles, were associated with 1.6- (95% CI 1.1–2.3), 1.6- (95% CI 1.1–2.4), and 1.4-fold (95% CI 0.95–1.9) increased risk of HCC, respectively. The GGA haplotype, comprised of risk alleles at rs867637, rs3771300 and rs2280235, conferred a 1.2-fold (95% CI 1.0–1.5) increased risk of HCC, as compared to the most common haplotype of ATG. Diplotype GGA/GGA conferred a 1.6-fold (95% CI 1.0–2.5) increased risk of HCC compared with diplotype ATG/ATG. 〈 i 〉 Conclusion: 〈 /i 〉 Our results demonstrate for the first time that polymorphisms in the 〈 i 〉 STAT1 〈 /i 〉 gene are associated with HCC susceptibility.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
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