In:
Israel Journal of Chemistry, Wiley, Vol. 55, No. 3-4 ( 2015-04), p. 325-335
Abstract:
We recently developed a facile synthesis to yield orthogonally protected mannose‐ and Gal‐β1,3/4‐GlcNAc‐containing oligosaccharides. With optimized reaction conditions, the protection/glycosylation steps were carried out in a successive manner, without purification of intermediate products. The entire development sequence is herein described in detail, including each installation and removal of protecting groups, the optimization of glycosylation reactions, the successive operation of reaction steps, and further applications for glycan synthesis. We also discuss the unsolved problems and current challenges.
Type of Medium:
Online Resource
ISSN:
0021-2148
,
1869-5868
DOI:
10.1002/ijch.v55.3/4
DOI:
10.1002/ijch.201400166
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2066481-3
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