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  • 1
    Online Resource
    Online Resource
    Molecular Simulations of Amyloid Structures, Toxicity, and Inhibition
    Wiley ; 2017
    In:  Israel Journal of Chemistry Vol. 57, No. 7-8 ( 2017-07), p. 586-601
    Details
    In: Israel Journal of Chemistry, Wiley, Vol. 57, No. 7-8 ( 2017-07), p. 586-601
    Abstract: The misfolding and aggregation of proteins and peptides into amyloid fibrils are believed to be responsible for the dysfunction and death of neuron cells in many neurodegenerative diseases. Resolving the atomic structures of amyloid peptides at different aggregation stages by molecular simulations has opened new ways to probe the molecular mechanisms of amyloid aggregation, toxicity, and inhibition, as well as to validate computational data with available experimental ones. In this review article, we summarize some recent and important findings on: 1) a number of atomic structures of amyloid oligomers with typical β‐sheet‐rich conformations, related to amyloid aggregation; 2) different amyloid peptide‐induced membrane‐disruption mechanisms, related to amyloid toxicity; and 3) rational design of different amyloid inhibitors capable of preventing amyloid aggregation and toxicity, related to amyloid inhibition. All these findings will provide some mechanistic implications for molecular mechanisms of amyloid aggregation, toxicity, and inhibition, which are fundamentally and practically important for the treatment of amyloid diseases.
    Type of Medium: Online Resource
    ISSN: 0021-2148 , 1869-5868
    URL: Issue
    URL: Article
    DOI: 10.1002/ijch.v57.7-8
    DOI: 10.1002/ijch.201600075
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2066481-3
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  • 2
    Online Resource
    Online Resource
    Effect of ammonia on the immune response of mud crab (Scylla paramamosain) and its susceptibility to mud crab reovirus
    SAABRON PRESS ; 2020
    In:  Israeli Journal of Aquaculture - Bamidgeh Vol. 72 ( 2020-10-3)
    Details
    In: Israeli Journal of Aquaculture - Bamidgeh, SAABRON PRESS, Vol. 72 ( 2020-10-3)
    Abstract: Ammonia is one of the major environmental pollutants that affect the growth and physiological functions of organisms. In the present study, the effects of ammonia on the immune response and pathogen resistance of mud crab reovirus (MCRV) in mud crab were investigated. Mud crab were exposed to four different ammonia concentrations (0, 2.5, 5 and 10 mg L-1 ammonia-N) for 7 d. The result showed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity significantly increased after 5 and 10 mg L-1 ammonia exposure. The hepatopancreas superoxide dismutase (SOD), catalase (CAT), and total antioxidative capacity (T-AOC) in ammonia-N group were significantly lower than those in the control group, while the levels of malondialdehyde (MDA) were significantly higher than those in the control group. Significant reductions in total hemocyte counts (THC) were observed after ammonia exposure. After 7d ammonia exposure, mud crabs were injected 100 μL MCRV at 105 copies/g body weight. The mortality of mud crabs in ammonia-N group were significantly higher than those in the control group. All these results suggested that ammonia in water caused a depression in the immune response, and increased susceptibility to MCRV infection.
    Type of Medium: Online Resource
    ISSN: 0792-156X , 0792-156X
    URL: Article
    DOI: 10.46989/001c.21468
    Language: English
    Publisher: SAABRON PRESS
    Publication Date: 2020
    detail.hit.zdb_id: 291787-7
    detail.hit.zdb_id: 2542938-3
    SSG: 21,3
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  • 3
    Online Resource
    Online Resource
    Effect of Feeding Rate on Growth Performance, Feed Utilization, and Blood-Chemistry Indicators of Nutritional Status in Juvenile Gift Strain Tilapia (Oreochromis Niloticus L.)
    SAABRON PRESS ; 2015
    In:  Israeli Journal of Aquaculture - Bamidgeh Vol. 67 ( 2015-1-1)
    Details
    In: Israeli Journal of Aquaculture - Bamidgeh, SAABRON PRESS, Vol. 67 ( 2015-1-1)
    Abstract: This study investigated the effect of feeding rates (2-10% of body weight), on the growth performance, feed utilization, and blood-chemistry indicators of nutritional status in juvenile GIFT strain tilapia, (Oreochromis niloticus) initial weight 72.73±0.15g. The 56 day trial conducted in cages tested five groups, with three replicates each. Fish were fed twice a day. Data were analyzed using one way ANOVA. Results showed that final body weight, food conversion rate (FCR), weight gain, specific growth rate (SGR), protein retention efficiency (PRE), protein efficiency ratio (PER), feed intake, and condition factor (CF) were significantly affected by the feeding rates (P 〈 0.05). The broken line method of linear regression analysis, y=17638x-217.9, R²=0.945; y=280x+860.6, R2=1, indicated that maximum weight gain occurred at 6.21% feeding rate. Insulin growth factor-one (IGF-I) level, hepatosomatic index (HSI), white blood cell (Wbc), red blood cell (Rbc), hemoglobin (Hb), and hematocrit (Ht) parameters were not significantly affected by the feeding rates (P 〉 0.05). Serum indicative parameters of liver-enzyme functions and food metabolism, including blood glucose (GLU), triglyceride (TG), total protein (TP) levels, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzyme activities were assayed. Blood glucose level of the fish was significantly affected by the feeding rates (P 〈 0.05). TG and TP levels; AST, ALT and ALP activities were not significantly affected by the feeding rates (P 〉 0.05). Feed provided at a rate of 2%-10% of body weight may meet physiological wellbeing of GIFT strain tilapia, however growth performance and other endocrine functions (IGF-I) are affected by lower and higher feeding rates. Our findings could be very useful to tilapia farmers.
    Type of Medium: Online Resource
    ISSN: 0792-156X , 0792-156X
    URL: Article
    DOI: 10.46989/001c.20722
    Language: English
    Publisher: SAABRON PRESS
    Publication Date: 2015
    detail.hit.zdb_id: 291787-7
    detail.hit.zdb_id: 2542938-3
    SSG: 21,3
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  • 4
    Online Resource
    Online Resource
    Impact of Functionalized Polystyrenes as the Electron Injection Layer on Gold and Aluminum Surfaces: A Combined Theoretical and Experimental Study
    Wiley ; 2014
    In:  Israel Journal of Chemistry Vol. 54, No. 5-6 ( 2014-06), p. 779-788
    Details
    In: Israel Journal of Chemistry, Wiley, Vol. 54, No. 5-6 ( 2014-06), p. 779-788
    Abstract: At metal/organic interfaces, the insertion of an organic monolayer can significantly modify the surface properties of the substrate, especially in terms of charge injection across the interface. Herein, we study the formation of an insulating monolayer of morpholine or amine‐functionalized polystyrene on Al(111) and Au(111) surfaces and its impact on surface work‐function and charge injection. First‐principles calculations based on Density Functional Theory have been carried out and point to a significant decrease in the work‐function of modified metal surfaces; this is in very good agreement with ultraviolet photoemission spectroscopy measurements performed on the Au(111) surface. In addition, a bilayer cathode, consisting of a thin film of high‐work‐function metal, such as Al and Au, and a layer of amine‐functionalized polystyrene, was also fabricated and tested in organic light‐emitting diodes. Such bilayer structures exhibit substantially enhanced efficiency when compared with controls without the functionalized polymers. Our combined theoretical and experimental investigation gives insight into how a thin layer of a commodity polymer can be used to transform rather high‐work‐function metals into high‐performance cathodes to provide efficient electron injection.
    Type of Medium: Online Resource
    ISSN: 0021-2148 , 1869-5868
    URL: Issue
    URL: Article
    DOI: 10.1002/ijch.v54.5/6
    DOI: 10.1002/ijch.201400041
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2066481-3
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  • 5
    Online Resource
    Online Resource
    Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems
    Wiley ; 2023
    In:  Israel Journal of Chemistry
    Details
    In: Israel Journal of Chemistry, Wiley
    Abstract: Truncated mucin‐type O‐glycans, such as Tn‐associated antigens, are aberrantly expressed biomarkers of cancer, but remain challenging to target. Reactive antibodies to these antigens either lack high affinity or are prone to antigen escape. Here, we have developed a robust chemoenzymatic strategy for the global labeling of Tn‐associated antigens, i. e. Tn (GalNAcα‐O‐Ser/Thr), Thomsen‐Friedenreich (Galβ1‐3GalNAcα‐O‐Ser/Thr, TF) and STF (Neu5Acα2‐3Galβ1‐3GalNAcα‐O‐Ser/Thr, STF) antigens, in human whole blood with high efficiency and selectivity. This method relies on the use of the O‐glycan sialyltransferase ST6GalNAc1 to transfer a sialic acid‐functionalized adaptor to the GalNAc residue of these antigens. By tagging, the adaptor functionalized antigens can be easily targeted by customized strategies such as, but not limited to, chimeric antigen receptor T‐Cells (CAR‐T). We expect this tagging system to find broad applications in cancer diagnostics and targeting in combination with established strategies.
    Type of Medium: Online Resource
    ISSN: 0021-2148 , 1869-5868
    URL: Article
    DOI: 10.1002/ijch.202300081
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2066481-3
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  • 6
    Online Resource
    Online Resource
    Chemoproteomic Profiling of O‐GlcNAcylation in Arabidopsis Thaliana by Using Metabolic Glycan Labeling
    Wiley ; 2023
    In:  Israel Journal of Chemistry Vol. 63, No. 1-2 ( 2023-02)
    Details
    In: Israel Journal of Chemistry, Wiley, Vol. 63, No. 1-2 ( 2023-02)
    Abstract: Protein O‐GlcNAcylation is a ubiquitous posttranslational modification occurring both in animals and plants. While thousands of O‐GlcNAcylated proteins have been identified in animals, the plant O‐GlcNAcylated proteome remains poorly studied. Herein we report the development of a chemoproteomic strategy for profiling of O‐GlcNAcylated proteins in Arabidopsis based on the metabolic glycan labeling (MGL) method. We first demonstrated that both N ‐azidoacetylglucosamine (GlcNAz) and N ‐azidoacetylgalactosamine (GalNAz) can metabolically label O‐GlcNAc with azides in Arabidopsis seedlings. Arabidopsis UDP‐galactose 4‐epimerases were found to interconvert UDP‐GalNAz and UDP‐GlcNAz, supporting the existence of a GalNAc metabolism pathway. By tagging the azide‐incorporated O‐GlcNAc with alkyne‐biotin via click chemistry, the O‐GlcNAcylated proteins were enriched and analyzed by mass spectrometry. We identified 645 candidate O‐GlcNAcylated proteins in Arabidopsis seedlings, of which 592 were newly identified. The identified O‐GlcNAcylated proteins were enriched in various plant‐specific processes such as hormone responses. By co‐expression of a selected list of the identified proteins with SECRET AGENT, the Arabidopsis O‐GlcNAc transferase, we validated that the MGL‐identified proteins were O‐GlcNAc‐modified. Our work establishes a powerful tool for profiling plant O‐GlcNAylation and provides an invaluable resource for investigating the functional role of O‐GlcNAc in Arabidopsis .
    Type of Medium: Online Resource
    ISSN: 0021-2148 , 1869-5868
    URL: Issue
    URL: Article
    DOI: 10.1002/ijch.v63.1-2
    DOI: 10.1002/ijch.202200065
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2066481-3
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