In:
Journal of Forensic Sciences, Wiley, Vol. 63, No. 2 ( 2018-03), p. 588-591
Abstract:
2‐(4‐Bromo‐2,5‐dimethoxyphenyl)‐N‐(2‐methoxybenzyl)ethanamine (25B‐ NBOM e) is a substituted phenethylamine, which has become highly prevalent worldwide since 2014. Recently, in an autopsy case involving fatal 25B‐ NBOM e intoxication, we found the postmortem increase of 25B‐ NBOM e concentration in the cardiac blood approximately 2 days after death. The aim of this study was to investigate the distribution of 25B‐ NBOM e and reproduce the postmortem redistribution using a rat model. Sprague‐Dawley rats were killed 30 min after intraperitoneal injection of 25B‐ NBOM e (0.5 mg/kg) and left for 0, 3, 6, 9, 15, or 24 h (six rats at each time point). Postmortem 25B‐ NBOM e concentrations in the cardiac blood increased by more than 10‐fold at 6‐h postmortem. 25B‐ NBOM e accumulated primarily in the lung. Moreover, this postmortem redistribution occurred even in rats that had died 1 week following the 25B‐ NBOM e administration. These findings indicate that attention should be paid to sample collection and data interpretation in the toxicological analysis of 25B‐ NBOM e.
Type of Medium:
Online Resource
ISSN:
0022-1198
,
1556-4029
DOI:
10.1111/jfo.2018.63.issue-2
DOI:
10.1111/1556-4029.13583
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2026357-0
SSG:
2,1
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