In:
Journal of Biochemical and Molecular Toxicology, Wiley, Vol. 36, No. 3 ( 2022-03)
Abstract:
The medical usage of Doxorubicin (DOX) as a chemotherapeutic agent is restricted owing to its cardiotoxic properties. This study was designed to explore the effect and underlying mechanisms of Citronellal (CT) on DOX‐related cardiotoxicity in rats. Rats were divided into six groups: control, DOX, CT, Lithium chloride (LiCl) (a Na+/H+exchanger‐1 [NHE1] activator), DOX + CT, and DOX + CT + LiCl. To induce cardiotoxicity, a cumulative dose of 15 mg/kg DOX was intraperitoneally injected into rats. CT (150 mg/kg) and LiCl (1 mg/kg) were given daily by oral gavage for 6 weeks. CT improved cardiac functional parameters and attenuated the cardiac pathological changes induced by DOX. Further study indicated that CT administration regulated the levels of oxidative stress and apoptosis‐related factors and in myocardial tissues, reducing cell per‐oxidative damage and apoptosis. Besides this, CT attenuated DOX‐induced NHE1 upregulation, and the preventive effects of CT against DOX‐induced cardiotoxicity were abrogated by the concurrent administration of LiCl. These results demonstrate that CT could ameliorate DOX‐induced cardiotoxicity by inhibiting the NHE1‐mediated oxidative stress, apoptosis in rats.
Type of Medium:
Online Resource
ISSN:
1095-6670
,
1099-0461
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1481995-8
SSG:
12
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