In:
Molecular Systems Biology, EMBO, Vol. 6, No. 1 ( 2010-01)
Abstract:
A well‐defined set of transcriptional regulatory modules was created and analyzed in the Drosophila embryo. Fractional occupancy‐based models were developed to explain the interaction of short range transcriptional repressors with endogenous activators by using quantitative data from these modules. Our fractional occupancy‐based modeling uncovered specific quantitative features of short‐range repressors; a complex nonlinear quenching relationship, similar quenching efficiencies for different activators, and modest levels of cooperativity The extension of the study to endogenous enhancers highlighted several features of enhancer architecture design in Drosophila embryos.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
Language:
English
Publisher:
EMBO
Publication Date:
2010
detail.hit.zdb_id:
2193510-5
SSG:
12
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