GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Bioscience, Biotechnology, and Biochemistry, Oxford University Press (OUP), ( 2023-09-14)
    Abstract: We focused on Piper longum L., an herbal drug produced in Myanmar, which has a renoprotective effect. Thus, we attempted to isolate and identify compounds that enhance the expression of the ABCG2 gene from the aerial parts of the plant except for the fruit. Among the various P. longum extracts, we isolated and identified the components. Using Caco-2 cells, the hABCG2 mRNA expression-enhancing effects of the isolated compounds were compared with the positive reference compound (3-methylcholanthrene: 3MC) using real-time PCR. Six compounds were isolated and identified from the methanol extract of P. longum. Among the isolated compounds, licarin A and neopomatene had lower toxicity and higher hABCG2-mRNA expression-enhancing effects in Caco-2 cells. Suppression of hAhR expression by siRNA reduced the activity of licarin A and neopomatene, as well as the hAhR agonist 3MC, suggesting that these two compounds may act as hAhR agonists to promote hABCG2 expression.
    Type of Medium: Online Resource
    ISSN: 1347-6947
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2110940-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: Chemistry & Biodiversity, Wiley, Vol. 18, No. 7 ( 2021-07)
    Abstract: Non‐alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the world, with a prevalence of 25 % in many countries. To date, no drug has been approved to treat NAFLD, therefore, the use of phytochemicals to prevent this disease is meaningful. In this study, we focused on the effects of Moringa oleifera Lam. on diabetes, attempted to isolate compounds that regulate NAFLD. Compounds 1 and 2 were isolated from the ethyl acetate fraction of M. oleifera . Spectral data revealed that they were 1‐hydroxy‐3‐phenylpropan‐2‐yl benzoate ( 1 ) and benzyl benzylcarbamate ( 2 ), respectively. The three‐dimensional structure of compound 1 was determined by single crystal X‐ray structural analysis. Neither compound was toxic to HepG2 cells, and compound 1 was found to have a concentration‐dependent inhibitory effect on intracellular lipid accumulation induced by stimulation of linoleic acid (LA). As a result of measuring the effects of compound 1 on the intracellular lipid production‐related protein, it was found that compound 1 enhanced protein expression that promotes lipolysis. On the other hand, since the action of compound 1 was similar to that of PPARα agonists, it is deduced that compound 1 enhanced the activity of PPARα and further enhanced the expression of lipolytic proteins, which is related to the suppression of intracellular lipid accumulation. Furthermore, as the result of docking simulation, compound 1 had a higher binding affinity to the ligand binding site of PPARα than fenofibrate, which is a PPARα agonist, and thus compound 1 was considered to be promising as an agonist of PPARα.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2139001-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    In: Conservation Biology, Wiley, Vol. 31, No. 6 ( 2017-12), p. 1257-1270
    Abstract: Temas de Transición Política y Conservación Emergente de los Bosques en Myanmar Resumen Las transiciones políticas y económicas han tenido impactos sustanciales sobre la conservación de los bosques. En los lugares donde se estén llevando a cabo las transiciones o donde se anticipen se deberían utilizar los precedentes históricos y los métodos para evaluar sistemáticamente las futuras tendencias para anticipar las amenazas probables a la conservación de los bosques y para diseñar medidas políticas apropiadas que se anticipen a las amenazas y las contrarresten. Myanmar está en una transición entre un estado autoritario centralizado con una economía altamente regulada y una democracia más descentralizada y liberal, además de estar trabajando para terminar con una guerra civil de larga duración. Con estas transiciones en mente utilizamos una estrategia de escaneo de horizonte para evaluar los 40 temas emergentes que más afectan a los bosques de Myanmar, incluyendo al conflicto interno, la inseguridad de la tenencia, el desarrollo agrícola a gran escala, la desaparición de las empresas estatales de madera, la escasez de ingresos públicos y capacidad, y la apertura de nuevas fronteras de deforestación con nuevas carreteras, minas y presas hidroeléctricas. Para evitar estas amenazas se requerirá de la revisión de los modelos de gobernanza, la capacidad de construcción, la mejora de la planeación de proyectos de energía e infraestructura, y la reforma de las leyes de tenencia y de protección ambiental, por citar algunos ejemplos. Aunque en Myanmar los retos para la conservación son abrumadores, la transición política ofrece una oportunidad para que los conservacionistas y los investigadores ayuden a formar un futuro que mejore el potencial social, económico y ambiental de Myanmar mientras se aprenden y aplican lecciones de otros países. Nuestra estrategia y sus resultados son relevantes para otros países pasando por transiciones similares.
    Type of Medium: Online Resource
    ISSN: 0888-8892 , 1523-1739
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020041-9
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...