In:
Chirality, Wiley, Vol. 17, No. 9 ( 2005-01), p. 570-576
Kurzfassung:
The positively charged quaternary ammonium cyclodextrin, QA‐β‐CD, was previously used as a chiral selector to achieve baseline resolution of two of the dianionic enantiomers of disodium 3‐( p ‐isothiocyanatophenoxy)‐3‐( p ‐isothiocyanatophenyl)propane‐1,2‐disulfate by capillary electrophoresis. The basis of the chiral discrimination between QA‐β‐CD and the enantiomers was investigated by 1 H NMR spectroscopy. COSY and NOESY spectra were used to infer the role that molecular interactions and the stereocenters have upon association of QA‐β‐CD with the enantiomers. A parallel two‐step complexation model is used to rationalize the NMR and the chiral discrimination observed during separation of the enantiomers. © 2005 Wiley‐Liss, Inc. Chirality 17:570–576, 2005.
Materialart:
Online-Ressource
ISSN:
0899-0042
,
1520-636X
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2005
ZDB Id:
2001237-8
SSG:
12
SSG:
15,3
Permalink