In:
The EMBO Journal, EMBO, Vol. 34, No. 18 ( 2015-09-14), p. 2350-2362
Abstract:
image Using a mouse knockout model for tRNA methyltransferase Dnmt2, this study identifies a link between translational fidelity and the differentiation of haematopoietic stem cells. tRNA methyltransferase Dnmt2 is required for cell‐autonomous differentiation during haematopoiesis. The loss of Dnmt2 disrupts proper differentiation of bone marrow MSC s. Dnmt2 is required for specific protein synthesis in the bone marrow. Dnmt2 ensures codon fidelity via the methylation of specific tRNA s.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201591382
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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