In:
Developmental Neurobiology, Wiley, Vol. 82, No. 7-8 ( 2022-10), p. 625-638
Abstract:
Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF‐κB signaling, p38 MAPK signaling, TREM2‐APOE signaling, ROCK signaling, C1q signaling, and Ion channel, which are involved in the activation, proliferation, and inflammation of microglia. This review aims to identify the microglia‐related molecular target and explore potential treatment strategies for MND based on that target.
Type of Medium:
Online Resource
ISSN:
1932-8451
,
1932-846X
DOI:
10.1002/dneu.v82.7-8
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2266191-8
SSG:
12
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