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  • Wiley  (11)
  • Biodiversity Research  (11)
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  • Biodiversity Research  (11)
  • 1
    Online Resource
    Online Resource
    Role of FEN1 S187 phosphorylation in counteracting oxygen‐induced stress and regulating postnatal heart development
    Wiley ; 2017
    In:  The FASEB Journal Vol. 31, No. 1 ( 2017-01), p. 132-147
    Details
    In: The FASEB Journal, Wiley, Vol. 31, No. 1 ( 2017-01), p. 132-147
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v31.1
    DOI: 10.1096/fj.201600631r
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    ZmXYL modulates auxin‐induced maize growth
    Wiley ; 2023
    In:  The Plant Journal Vol. 115, No. 6 ( 2023-09), p. 1699-1715
    Details
    In: The Plant Journal, Wiley, Vol. 115, No. 6 ( 2023-09), p. 1699-1715
    Abstract: Our study is the first to probe the role of an α‐xylosidase, ZmXYL, in mediating maize growth via modulating auxin homeostasis. ZmXYL functions to cleave xylosyl residues from the XyG chain. Mutation of ZmXYL in xyl mutants results in an increased XXXG content embedded in XyG and a reduced sensitivity to auxin. Our findings suggest that auxin exhibits an antagonistic association with XXXG and that XXXG acts as a signal molecule to attenuate auxin biosynthesis.
    Type of Medium: Online Resource
    ISSN: 0960-7412 , 1365-313X
    URL: Issue
    URL: Article
    DOI: 10.1111/tpj.v115.6
    DOI: 10.1111/tpj.16348
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020961-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    MADS‐box transcription factor Mcm1 controls cell cycle, fungal development, cell integrity and virulence in the filamentous insect pathogenic fungus Beauveria bassiana
    Wiley ; 2019
    In:  Environmental Microbiology Vol. 21, No. 9 ( 2019-09), p. 3392-3416
    Details
    In: Environmental Microbiology, Wiley, Vol. 21, No. 9 ( 2019-09), p. 3392-3416
    Abstract: MADS‐box transcription factor Mcm1 plays crucial roles in regulating mating processes and pathogenesis in some fungi. However, its roles are varied in fungal species, and its function remains unclear in entomopathogenic fungi. Here, Mcm1 orthologue, Bbmcm1, was characterized in a filamentous entomopathogenic fungus, Beauveria bassiana . Disruption of Bbmcm1 resulted in a distinct reduction in growth with abnormal conidiogenesis, and a significant decrease in conidial viability with abnormal germination. Δ Bbmcm1 displayed impaired cell integrity, with distorted cell wall structure and altered cell wall component. Abnormal cell cycle was detected in Δ Bbmcm1 with longer G 2 /M phase but shorter G 1 /G 0 and S phases in unicellular blastospores, and sparser septa in multicellular hyphae, which might be responsible for defects in development and differentiation due to the regulation of cell cycle‐involved genes, as well as the corresponding cellular events‐associated genes. Dramatically decreased virulence was examined in Δ Bbmcm1 , with impaired ability to escape haemocyte encapsulation, which was consistent with markedly reduced cuticle‐degrading enzyme production by repressing their coding genes, and downregulated fungal effector protein‐coding genes, suggesting a novel role of Mcm1 in interaction with host insect. These data indicate that Mcm1 is a crucial regulator of development, cell integrity, cell cycle and virulence in insect fungal pathogens.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.v21.9
    DOI: 10.1111/1462-2920.14629
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2020213-1
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Fus3/ Kss1‐MAP kinase and Ste12‐like control distinct biocontrol‐traits besides regulation of insect cuticle penetration via phosphorylation cascade in a filamentous fungal pathogen
    Wiley ; 2023
    In:  Pest Management Science Vol. 79, No. 7 ( 2023-07), p. 2611-2624
    Details
    In: Pest Management Science, Wiley, Vol. 79, No. 7 ( 2023-07), p. 2611-2624
    Abstract: Homolog of the yeast Fus3/Kss1 mitogen‐activated protein kinase (MAPK) pathway and its target transcription factor, Ste12‐like, are involved in penetration of host cuticle/pathogenicity in many ascomycete pathogens. However, details of their interaction during fungal infection, as well as their controlled other virulence‐associated traits, are unclear. RESULTS Ste12‐like (BbSte12) and Fus3/Kss1 MAPK homolog (Bbmpk1) interacted in nucleus, and phosphorylation of BbSte12 by Bbmpk1 was essential for penetration of insect cuticle in an insect fungal pathogen, Beauveria bassiana . However, some distinct biocontrol‐traits were found to be mediated by Ste12 and Bbmpk1. In contrast to Δ Bbmpk1 colony that grew more rapid than wild‐type strain, inactivation of BbSte12 resulted in the opposite phenotype, which was consistent with their different proliferation rates in insect hemocoel after direct injection of conidia bypass the cuticle. Reduced conidial yield with decreased hydrophobicity was examined in both mutants, however they displayed distinct conidiogenesis, accompanying with differently altered cell cycle, distinct hyphal branching and septum formation. Moreover, Δ Bbmpk1 showed increased tolerance to oxidative agent, whereas the opposite phenotype was seen for Δ BbSte12 strain. RNA sequencing analysis revealed that Bbmpk1 controlled 356 genes depending on BbSte12 during cuticle penetration, but 1077 and 584 genes were independently controlled by Bbmpk1 and BbSte12. CONCLUSION BbSte12 and Bbmpk1 separately participate in additional pathways for control of conidiation, growth and hyphal differentiation, as well as oxidative stress response besides regulating cuticle penetration via phosphorylation cascade. © 2023 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v79.7
    DOI: 10.1002/ps.7446
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Anti‐PD‐1 therapy for advanced colorectal cancer based on intestinal microecology
    Wiley ; 2023
    In:  Journal of Biochemical and Molecular Toxicology Vol. 37, No. 10 ( 2023-10)
    Details
    In: Journal of Biochemical and Molecular Toxicology, Wiley, Vol. 37, No. 10 ( 2023-10)
    Abstract: To explore the effects of anti‐programmed death‐1 (PD‐1) therapy on advanced colorectal cancer (CRC) based on the intestinal microecology. Ninety‐two patients with advanced CRC were selected. Patients were treated with Apatinib alone or anti PD‐1 treatment combined with Apatinib. The lactulose/mannitol (L/M) value of the urine was detected by high performance liquid chromatography. The changes of intestinal microflora were determined by real‐time fluorescence quantitative PCR. The risk factors were analyzed through multivariate logistic regression analysis. The curative effect of anti PD‐1 treatment combined with the Apatinib treatment (82.61%) was much higher than that of the Apatinib treatment alone (63.04%, p   〈  0.05). After treatment, the contents of Bifidobacterium, Lactobacillus , and Enterococcus faecalis were higher with lower levels of Escherichia coli in the observation group than the control ( p   〈  0.05). The level of D‐lactic acid and urinary L/M value of the urine in the observation group was lower than that in control after treatment ( p   〈  0.001). The patients had a 3‐year survival rate of 91.30%. Age 〉 60 years old, histological types of mucinous adenocarcinoma and signet ring cell carcinoma, vascular tumor thrombus, nerve invasion, TNM stage of Ⅲ−Ⅳ were independent risk factors, and anti PD‐1 treatment was the protective factor ( p   〈  0.05). In advanced CRC patients receiving anti PD‐1 treatment combined with the Apatinib treatment, the progression of advanced CRC was effectively controlled by maintaining the intestinal microflora balance. Anti PD‐1 therapy can improve the living quality of CRC patients.
    Type of Medium: Online Resource
    ISSN: 1095-6670 , 1099-0461
    URL: Issue
    URL: Article
    DOI: 10.1002/jbt.v37.10
    DOI: 10.1002/jbt.23438
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1481995-8
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates and defective in myopathy
    Wiley ; 2010
    In:  The FASEB Journal Vol. 24, No. S1 ( 2010-04)
    Details
    In: The FASEB Journal, Wiley, Vol. 24, No. S1 ( 2010-04)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v24.S1
    DOI: 10.1096/fasebj.24.1_supplement.646.1
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1468876-1
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  • 7
    Online Resource
    Online Resource
    The fungal mitochondrial membrane protein, BbOhmm, antagonistically controls hypoxia tolerance
    Wiley ; 2020
    In:  Environmental Microbiology Vol. 22, No. 7 ( 2020-07), p. 2514-2535
    Details
    In: Environmental Microbiology, Wiley, Vol. 22, No. 7 ( 2020-07), p. 2514-2535
    Abstract: Adaptation to low‐oxygen (LO) environment in host tissues is crucial for microbial pathogens, particularly fungi, to successfully infect target hosts. However, the underlying mechanisms responsible for hypoxia tolerance in most pathogens are poorly understood. A mitochondrial protein, BbOhmm, is demonstrated to limit oxidative stress resistance and virulence in the insect fungal pathogen, Beauveria bassiana . Here, we found that BbOhmm negatively affected hypoxic adaptation in the insect haemocoel while regulating respiration‐related events, heme synthesis and mitochondrial iron homeostasis. A homologue of the mammalian sterol regulatory element‐binding proteins (SREBPs), BbSre1, was shown to be involved in BbOhmm‐mediated LO adaptation. Inactivation of BbSre1 resulted in a significant increase in sensitivity to hypoxic and oxidative stress. Similar to ΔBbOhmm , ΔBbSre1 or the ΔBbOhmmΔBbSre1 double mutant accumulated high levels of heme and mitochondrial iron, regulating the similar pathways during hypoxic stress. BbSre1 transcriptional activity and nuclear import were repressed in ΔBbOhmm cells and affected by intracellular reactive oxygen species (ROS) and oxygen levels. These findings have led to a new model in which BbOhmm affects ROS homeostasis in combination with available oxygen to control the transcriptional activity of BbSre1, which in turn mediates LO adaptation by regulating mitochondrial iron homeostasis, heme synthesis and respiration‐implicated genes.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.v22.7
    DOI: 10.1111/1462-2920.14910
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020213-1
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  • 8
    Online Resource
    Online Resource
    T4 ‐like myovirus community shaped by dispersal and deterministic processes in the South China Sea
    Wiley ; 2021
    In:  Environmental Microbiology Vol. 23, No. 2 ( 2021-02), p. 1038-1052
    Details
    In: Environmental Microbiology, Wiley, Vol. 23, No. 2 ( 2021-02), p. 1038-1052
    Abstract: As the most abundant and genetically diverse biological entities, viruses significantly influence ecological, biogeographical and evolutionary processes in the ocean. However, the biogeography of marine viruses and the drivers shaping viral community are unclear. Here, the biogeographic patterns of T4‐like viruses and the relative impacts of deterministic (environmental selection) and dispersal (spatial distance) processes were investigated in the northern South China Sea. The dominant viral operational taxonomic units were affiliated with previously defined Marine, Estuary, Lake and Paddy Groups. A clear viral biogeographic pattern was observed along the environmental gradient from the estuary to open sea. Marine Groups I and IV had a wide geographical distribution, whereas Marine Groups II, III and V were abundant in lower‐salinity continental or eutrophic environments. A significant distance‐decay pattern was noted for the T4‐like viral community, especially for those infecting cyanobacteria. Both deterministic and dispersal processes influenced viral community assembly, although environmental selection (e.g. temperature, salinity, bacterial abundance and community, etc.) had a greater impact than spatial distance. Network analysis confirmed the strong association between viral and bacterial community composition, and suggested a diverse ecological relationship (e.g. lysis, co‐infection or mutualistic) between and within viruses and their potential bacterial hosts.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.v23.2
    DOI: 10.1111/1462-2920.15290
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020213-1
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Multifunctional role of a fungal pathogen‐secreted laccase 2 in evasion of insect immune defense
    Wiley ; 2021
    In:  Environmental Microbiology Vol. 23, No. 2 ( 2021-02), p. 1256-1274
    Details
    In: Environmental Microbiology, Wiley, Vol. 23, No. 2 ( 2021-02), p. 1256-1274
    Abstract: Laccases are widely present in bacteria, fungi, plants and invertebrates and involved in a variety of physiological functions. Here, we report that Beauveria bassiana , an economic important entomopathogenic fungus, secretes a laccase 2 (BbLac2) during infection that detoxifies insect immune response‐generated reactive oxygen species (ROS) and interferes with host immune phenoloxidase (PO) activation. BbLac2 is expressed in fungal cells during proliferation in the insect haemocoel and can be found to distribute on the surface of haemolymph‐derived in vivo fungal hyphal bodies or be secreted. Targeted gene‐knockout of BbLac2 increased fungal sensitivity to oxidative stress, decreased virulence to insect, and increased host PO activity. Strains overexpressing BbLac2 showed increased virulence, with reduced host PO activity and lowered ROS levels in infected insects. In vitro assays revealed that BbLac2 could eliminate ROS and oxidize PO substrates (phenols), verifying the enzymatic functioning of the protein in detoxification of cytotoxic ROS and interference with the PO cascade. Moreover, BbLac2 acted as a cell surface protein that masked pathogen associated molecular patterns (PAMPs), enabling the pathogen to evade immune recognition. Our data suggest a multifunctional role for fungal pathogen‐secreted laccase 2 in evasion of insect immune defenses.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.v23.2
    DOI: 10.1111/1462-2920.15378
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020213-1
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  • 10
    Online Resource
    Online Resource
    A secretory phospholipase A2 of a fungal pathogen contributes to lipid droplet homeostasis, assimilation of insect‐derived lipids, and repression of host immune responses
    Wiley ; 2022
    In:  Insect Science Vol. 29, No. 6 ( 2022-12), p. 1685-1702
    Details
    In: Insect Science, Wiley, Vol. 29, No. 6 ( 2022-12), p. 1685-1702
    Abstract: Secretory phospholipase A2s (sPLA2s) are found in a wide range of organisms from bacteria to higher plants and animals and are involved in varied and cellular processes. However, roles of these enzymes in microbial pathogens remain unclear. Here, an sPLA2 (BbPLA2) was characterized in the filamentous insect pathogenic fungus, Beauveria bassiana . BbPLA2 was exclusively expressed in insect hemolymph‐derived cells (hyphal bodies), and its expression was induced by insect‐derived nutrients and lipids, and nutrient starvation. High levels of secretion of BbPLA2 were observed as well as its distribution in hyphal body lipid drops (LDs). Overexpression of BbPLA2 increased the ability of B. bassiana to utilize insect‐derived nutrients and lipids, and promoted LD accumulation, indicating functions for BbPLA2 in mediating LD homeostasis and assimilation of insect‐derived lipids. Strains overexpressing BbPLA2 showed moderately increased virulence, including more efficient penetration of the insect cuticle and evasion of host immune responses as compared to the wild type strain. In addition, B. bassiana ‐activated host immune genes were downregulated in the BbPLA2 overexpression strain, but upregulated by infections with a ΔBbPLA2 strain. These data demonstrate that BbPLA2 contributes to LD homeostasis, assimilation of insect‐derived lipids, and repression of host immune responses.
    Type of Medium: Online Resource
    ISSN: 1672-9609 , 1744-7917
    URL: Issue
    URL: Article
    DOI: 10.1111/ins.v29.6
    DOI: 10.1111/1744-7917.13029
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2179775-4
    SSG: 12
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