In:
The EMBO Journal, EMBO, Vol. 42, No. 1 ( 2023-01-04)
Abstract:
image How inflammasome activation is orchestrated by specific organelles remains unclear. Here, the lysosomal Ragulator complex is shown to enhance NLRP3 inflammasome activation via histone deacetylase 6 (HDAC6). Deficiency of Lamtor1, an essential component of the Ragulator complex, abrogated NLRP3 inflammasome activation in vitro and in mice. Lamtor1 interacted with NLRP3 and HDAC6. HDAC6 enhances the interaction between Lamtor1 and NLRP3. DL‐all‐rac‐α‐tocopherol, a synthetic form of vitamin E, inhibited the Lamtor1–HDAC6 interaction, resulting in diminished NLRP3 inflammasome activation.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022111389
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
Permalink