In:
EMBO reports, EMBO, Vol. 24, No. 9 ( 2023-09-06)
Abstract:
image Dual specificity phosphatase 1 (DUSP1) in the medial prefrontal cortex (mPFC) mediates adolescent cocaine exposure‐induced higher sensitivity to the drug in adulthood, providing a potential target to predict or treat the susceptibility to addictive drugs. Adolescent cocaine exposure (ACE) causes higher cocaine‐preferred behaviors during adulthood, along with more activated CaMKII‐positive neurons, higher Dusp1 mRNA, and lower DUSP1 protein and protein activity in the mPFC. Overexpressing rather than knocking‐down DUSP1 in CaMKII‐positive neurons suppresses mPFC activation and alleviates cocaine‐preferred behaviors in ACE mice during adulthood.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202356981
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12
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