In:
Bioscience Reports, Portland Press Ltd., Vol. 19, No. 4 ( 1999-08-01), p. 261-271
Abstract:
Adherence of Plasmodium falciparum-infected erythrocytes (PRBCs) to the microvascular endothelium of specific organs and consequent sequestration is believed to be responsible for the development of malaria pathology. A number of studies have shown that cell adhesion molecules expressed on the surface of endothelial cells mediate the adherence. Recent studies indicate that a subpopulation of PRBCs adhere to chondroitin 4-sulfate (C4S). This adhesion can be effectively inhibited by C4S oligosaccharides. In pregnant women, the placenta specifically selects C4S-adherent PRBCs, and thus these phenotypes multiply and sequester in the intervillous spaces. Over successive pregnancies, women develop a protective humoral response to the C4S-adhesion phenotype. Disruption of C4S-mediated PRBCs adhesion using either a C4S oligosaccharide mimetic or an antiC4S-adhesion vaccine can be an efficient strategy for the treatment of malaria caused by C4S-adherent P. falciparum.
Type of Medium:
Online Resource
ISSN:
0144-8463
,
1573-4935
DOI:
10.1023/A:1020542206916
Language:
English
Publisher:
Portland Press Ltd.
Publication Date:
1999
detail.hit.zdb_id:
2014993-1
SSG:
12
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