In:
The Journal of Neuroscience, Society for Neuroscience, Vol. 18, No. 7 ( 1998-04-01), p. 2520-2537
Kurzfassung:
Gap junctions are highly conductive channels that allow the direct transfer of intracellular messengers such as Ca 2+ and inositol triphosphate (IP 3 ) between interconnected cells. In brain, astrocytes are coupled extensively by gap junctions. We found here that gap junctions among astrocytes in acutely prepared brain slices as well as in culture remained open during ischemic conditions. Uncoupling first occurred after the terminal loss of plasma membrane integrity. Gap junctions therefore may link ischemic astrocytes in an evolving infarct with the surroundings. The free exchange of intracellular messengers between dying and potentially viable astrocytes might contribute to secondary expansion of ischemic lesions.
Materialart:
Online-Ressource
ISSN:
0270-6474
,
1529-2401
DOI:
10.1523/JNEUROSCI.18-07-02520.1998
Sprache:
Englisch
Verlag:
Society for Neuroscience
Publikationsdatum:
1998
ZDB Id:
1475274-8
SSG:
12
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