In:
Bioinformatics, Oxford University Press (OUP), Vol. 24, No. 15 ( 2008-08-01), p. 1737-1739
Abstract:
Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. Availability: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/ Contact: heping.zhang@yale.edu
Type of Medium:
Online Resource
ISSN:
1367-4811
,
1367-4803
DOI:
10.1093/bioinformatics/btn258
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2008
detail.hit.zdb_id:
1468345-3
SSG:
12
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