In:
Chemistry & Biodiversity, Wiley, Vol. 19, No. 9 ( 2022-09)
Abstract:
Six new polyoxygenated xanthones, garcicowanones F–H ( 1 ‐ 3 ), norcowanol A–B ( 4 ‐ 5 ), and garcinone F ( 6 ) along with twelve known compounds 7 – 18 were obtained from the latex of Garcinia cowa Roxb. ex Choisy. All new compounds have a 1,3,7‐trioxygenated or 1,3,6,7‐tetraoxygenated xanthone nucleus and differ from majority of xanthones from G. cowa by hydrated side chains. Compounds 1 , 7 , 8 and 18 exhibited significant neuroprotective effects on glutamate‐mediated hippocampal neuronal HT22 cell death. In particular, compound 1 exhibited the most potent neuroprotective effect with 〉 80 % cell viability in the concentration range of 2.9–115 μM. Further studies on compound 1 showed that it decreased cellular Ca 2+ influx and inhibits cellular reactive oxygen species generation in HT22 cells. A Western blot analysis showed that MAPK phosphorylation, Bax, and AIF translocation dramatically increased upon treatment with 5 mM glutamate and decreased upon a co‐treatment with compound 1 .
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202200376
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2139001-0
SSG:
12
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