In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 28, No. 4 ( 2014-02-15), p. 409-421
Abstract:
Genetic basis of phenotypic differences in individuals is an important area in biology and personalized medicine. Analysis of divergent Saccharomyces cerevisiae strains grown under different conditions revealed extensive variation in response to both drugs (e.g., 4-nitroquinoline 1-oxide [4NQO]) and different carbon sources. Differences in 4NQO resistance were due to amino acid variation in the transcription factor Yrr1. Yrr1 YJM789 conferred 4NQO resistance but caused slower growth on glycerol, and vice versa with Yrr1 S96 , indicating that alleles of Yrr1 confer distinct phenotypes. The binding targets of Yrr1 alleles from diverse yeast strains varied considerably among different strains grown under the same conditions as well as for the same strain under different conditions, indicating that distinct molecular programs are conferred by the different Yrr1 alleles. Our results demonstrate that genetic variations in one important control gene ( YRR1 ), lead to distinct regulatory programs and phenotypes in individuals. We term these polymorphic control genes “master variators.”
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
DOI:
10.1101/gad.228940.113
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2014
detail.hit.zdb_id:
1467414-2
SSG:
12
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