In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 78, No. 1 ( 1981-01), p. 323-327
Abstract:
Histamine was detected at levels of 100 ng/10(6) cells in the metachromatic granules of the persisting (P) cell, which appears in cultures of murine lymphoid or bone marrow cells and is capable of long-term growth in vitro in the presence of a T cell-derived growth factor. This factor, which we termed P-cell stimulating factor, was distinct from t-cell growth factor and had an apparent molecular weight of 25,000-30,000. P cells did not originate from Thy.1-positive cells nor was the thymus necessary for the development of their precursors. Moreover, P cells grew directly from colonies generated in agar cultures of bone marrow cells, the nature of the colonies indicating that P cells shared a common precursor with hemopoietic cells. Mutant Wf/Wf mice, although deficient in certain mast cells, possessed P-cell precursors. It is hypothesized that P cells are related to a specialized subset of mast cells, derived from a bone marrow progenitor but regulated by activated T cells.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.78.1.323
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
1981
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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