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  • 1
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    Haliea alexandrii sp. nov., isolated from phycosphere microbiota of the toxin-producing dinoflagellate Alexandrium catenella
    Microbiology Society ; 2020
    In:  International Journal of Systematic and Evolutionary Microbiology Vol. 70, No. 2 ( 2020-02-01), p. 1133-1138
    Details
    In: International Journal of Systematic and Evolutionary Microbiology, Microbiology Society, Vol. 70, No. 2 ( 2020-02-01), p. 1133-1138
    Abstract: A Gram-negative, aerobic, non-motile, non-spore-forming and rod-shaped bacterium, named strain LZ-16-2 T , was isolated from the phycosphere microbiota of the paralytic shellfish poisoning toxin-producing marine dinoflagellate Alexandrium catenella LZT09. Strain LZ-16-2 T grew optimally at 28 °C at pH 6.5 and with 3 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequence revealed that strain LZ-16-2 T fell within the genus Haliea and was most closely related to Haliea salexigens DSM 19537 T , with which the new isolate exhibited 98.5 % 16S rRNA gene sequence similarity. The major respiratory quinone was Q-8. The predominant cellular fatty acids were C 17 : 1   ω8 c , summed feature 3 (C 16 : 1   ω7 c and/or C 16 : 1   ω6 c ), summed feature 8 (C 18 : 1   ω7 c and/or C 18 : 1   ω6 c ), C 17 : 1   ω6 c , C 11 : 0 3-OH and C 17 : 0 . The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol and diphosphatidylglycerol. The average nucleotide identity and in silico DNA–DNA genome hybridization relatedness values between strain LZ-16-2 T and its closest relative, H. salexigens DSM 19537 T , were 92.8 and 55.1 %, respectively. The DNA G+C content was 61.3 mol%. Differential phenotypic properties and phylogenetic distinctiveness distinguished strain LZ-16-2 T from all other members of the genus Haliea . On the basis of the polyphasic characterization, strain LZ-16-2 T represents a novel species of the genus Haliea , for which the name Haliea alexandrii sp. nov. is proposed. The type strain is LZ-16-2 T (=KCTC 62344 T =CCTCC AB2017229 T ).
    Type of Medium: Online Resource
    ISSN: 1466-5026 , 1466-5034
    URL: Article
    DOI: 10.1099/ijsem.0.003890
    Language: English
    Publisher: Microbiology Society
    Publication Date: 2020
    detail.hit.zdb_id: 215062-1
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  • 2
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    D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1
    Proceedings of the National Academy of Sciences ; 2022
    In:  Proceedings of the National Academy of Sciences Vol. 119, No. 8 ( 2022-02-22)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 8 ( 2022-02-22)
    Abstract: Breast cancer is the most frequent malignancy in women worldwide, and triple-negative breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The therapeutic strategies for TNBC are limited. It is urgent to develop new methods to enhance the efficacy of TNBC treatment. Previous studies demonstrated that D-mannose, a hexose, can enhance chemotherapy in cancer and suppress the immunopathology of autoimmune diseases. Here, we show that D-mannose can significantly facilitate TNBC treatment via degradation of PD-L1. Specifically, D-mannose can activate AMP-activated protein kinase (AMPK) to phosphorylate PD-L1 at S195, which leads to abnormal glycosylation and proteasomal degradation of PD-L1. D-mannose–mediated PD-L1 degradation promotes T cell activation and T cell killing of tumor cells. The combination of D-mannose and PD-1 blockade therapy dramatically inhibits TNBC growth and extends the lifespan of tumor-bearing mice. Moreover, D-mannose–induced PD-L1 degradation also results in messenger RNA destabilization of DNA damage repair–related genes, thereby sensitizing breast cancer cells to ionizing radiation (IR) treatment and facilitating radiotherapy of TNBC in mice. Of note, the effective level of D-mannose can be easily achieved by oral administration in mice. Our study unveils a mechanism by which D-mannose targets PD-L1 for degradation and provides methods to facilitate immunotherapy and radiotherapy in TNBC. This function of D-mannose may be useful for clinical treatment of TNBC.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2114851119
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2022
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    detail.hit.zdb_id: 1461794-8
    SSG: 11
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  • 3
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    Genome‐wide identification and characterization of basic helix‐loop‐helix transcription factors in Spodoptera litura upon pathogen infection
    Wiley ; 2022
    In:  Insect Science Vol. 29, No. 4 ( 2022-08), p. 977-992
    Details
    In: Insect Science, Wiley, Vol. 29, No. 4 ( 2022-08), p. 977-992
    Abstract: Basic helix‐loop‐helix (bHLH) transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes, and bHLH proteins also participate in immune responses, especially in plants. However, their roles in insects upon entomopathogen infection are unknown. In this study, 54 bHLH genes in 41 families were identified in a polyphagous pest, Spodoptera litura , including a new bHLH gene in group B, which is specifically present in Lepidoptera and was thus named Lep . The conserved amino acids in the bHLH domain, structural architecture, and chromosomal distribution of bHLH genes in S. litura were analyzed. The bHLH genes in Plutella xylostella and Apis mellifera were also updated, and genome‐wide comparison and phylogenetic analysis of bHLH members in 5 holometabolous insects were performed. The expression profiles of S. litura bHLH ( SlbHLH ) genes in 3 tissues at different developmental stages and their responses to S. litura nucleopolyhedrovirus (SpltNPV), Nomuraea rileyi (Nr), and Bacillus thuringiensis (Bt) infection were investigated. More SlbHLHs in group B were expressed and differentially expressed during pathogen infections, and SlbHLHs tended to be downregulated in the midgut of S. litura larvae after B. thuringiensis treatment. Our study provides an overview of bHLH family members in S. litura and their responses to different pathogens used for pest biocontrol. These findings on bHLH members may contribute to uncovering the mechanism of host–pathogen interaction.
    Type of Medium: Online Resource
    ISSN: 1672-9609 , 1744-7917
    URL: Issue
    URL: Article
    DOI: 10.1111/ins.v29.4
    DOI: 10.1111/1744-7917.12979
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2179775-4
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  • 4
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    The cell invasion preference of Varroa destructor between the original and new honey bee hosts
    Elsevier BV ; 2022
    In:  International Journal for Parasitology Vol. 52, No. 2-3 ( 2022-02), p. 125-134
    Details
    In: International Journal for Parasitology, Elsevier BV, Vol. 52, No. 2-3 ( 2022-02), p. 125-134
    Type of Medium: Online Resource
    ISSN: 0020-7519
    URL: Article
    DOI: 10.1016/j.ijpara.2021.08.001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2011817-X
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  • 5
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    Comparative genomic analysis of C-type lectin-domain genes in seven holometabolous insect species
    Elsevier BV ; 2020
    In:  Insect Biochemistry and Molecular Biology Vol. 126 ( 2020-11), p. 103451-
    Details
    In: Insect Biochemistry and Molecular Biology, Elsevier BV, Vol. 126 ( 2020-11), p. 103451-
    Type of Medium: Online Resource
    ISSN: 0965-1748
    URL: Article
    DOI: 10.1016/j.ibmb.2020.103451
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1483248-3
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  • 6
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    Genome‐wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura
    Wiley ; 2022
    In:  Insect Science Vol. 29, No. 3 ( 2022-06), p. 783-800
    Details
    In: Insect Science, Wiley, Vol. 29, No. 3 ( 2022-06), p. 783-800
    Abstract: Cadherin, aminopeptidase N (APN) and alkaline phosphatase (ALP) have been characterized as Cry receptors. In this study, comparative genomic analysis of the 3 receptor families was performed in 7 insects. ALPs and APNs are divided into three and eight clades in phylogenetic trees, respectively. ALPs in clade 3 and APNs in clade 1 contain multiple paralogs within each species and most paralogs are located closely in chromosomes. Drosophila melanogaster has expanded APNs in clade 5 and were lowly expressed in midgut. Cadherins are divided into 16 clades; they may diverge before holometabolous insect speciation except for BtR and Cad89D‐like clades. Eight insects from different orders containing BtR orthologs are sensitive to Cry1A or Cry3A, while five species without BtR are insensitive to both toxins. Most APNs in clade 1, several ALPs in clade 3, BtR and Cad89D‐like genes were highly or moderately expressed in larval midgut of Spodoptera litura and the other six species, and several members in these clades have been identified as Cry receptors. Expressions of putative S. litura Cry receptors in the midgut after exposing to Bt toxins were also analyzed.
    Type of Medium: Online Resource
    ISSN: 1672-9609 , 1744-7917
    URL: Issue
    URL: Article
    DOI: 10.1111/ins.v29.3
    DOI: 10.1111/1744-7917.12961
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2179775-4
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  • 7
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    Nioella ostreopsis sp. nov., isolated from toxic dinoflagellate, Ostreopsis lenticularis
    Microbiology Society ; 2020
    In:  International Journal of Systematic and Evolutionary Microbiology Vol. 70, No. 2 ( 2020-02-01), p. 759-765
    Details
    In: International Journal of Systematic and Evolutionary Microbiology, Microbiology Society, Vol. 70, No. 2 ( 2020-02-01), p. 759-765
    Abstract: A novel short-rod-shaped bacterial strain with poly-β-hydroxybutyric acid granules inside, designated as Z7-4 T , was isolated from a culture of a marine dinoflagellate with palytoxin-producing capacity, Ostreopsis lenticularis OS06, collected from the East China Sea. Cells of Z7-4 T were Gram-stain-negative, non-motile, strictly aerobic, 0.9–1.2 µm wide and 2.0–3.9 µm long. Growth occurred in 1–4 % (w/v) NaCl, at 15–37 °C and at pH 5.0–10.0, with optimum growth in 3.5 % (w/v) NaCl, at 30 °C and at pH 7.0. Analysis of 16S rRNA gene sequence revealed that Z7-4 T shared the highest 16S rRNA gene sequence similarities with Nioella aestuarii JCM 30752 T (98.8 %), followed by Nioella sediminis KCTC 42144 T (98.6 %) and Nioella nitratireducens KCTC 32417 T (96.9 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that Z7-4 T clearly represented a member of the genus Nioella within the family Rhodobacteraceae . The respiratory quinone of Z7-4 T was identified as Q-10. Polar lipids of Z7-4 T were phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, three unidentified aminophospholipids and one unidentified phospholipid. The major fatty acids were summed feature 8 (C 18 : 1 ω7 c and/or C 18 : 1 ω6 c ) and C 16 : 0 . The DNA G+C content of Z7-4 T was 63.0 mol%. DNA–DNA hybridization values of the isolate against the closely related type strains were far below the 70 % limit for species delineation. The average nucleotide identity and in silico DNA–DNA genome hybridization relatedness between Z7-4 T and the closely related members of the genus Nioella , N. sediminis KCTC 42144 T and N. nitratireducens KCTC 32417 T , were 91.1 and 46.3 %, and 79.3 and 19.4 %, respectively. On the basis of the results of polyphasic analysis, Z7-4 T is proposed to represent a novel species of the genus Nioella , for which the name Nioella ostreopsis sp. nov. is proposed. The type strain of Nioella ostreopsis is Z7-4 T (=KCTC 62459 T =CCTCC AB 2017231 T )
    Type of Medium: Online Resource
    ISSN: 1466-5026 , 1466-5034
    URL: Article
    DOI: 10.1099/ijsem.0.003816
    Language: English
    Publisher: Microbiology Society
    Publication Date: 2020
    detail.hit.zdb_id: 215062-1
    detail.hit.zdb_id: 2056611-6
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  • 8
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    Toll9 from Bombyx mori functions as a pattern recognition receptor that shares features with Toll-like receptor 4 from mammals
    Proceedings of the National Academy of Sciences ; 2021
    In:  Proceedings of the National Academy of Sciences Vol. 118, No. 19 ( 2021-05-11)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 118, No. 19 ( 2021-05-11)
    Abstract: Toll/Toll-like receptors (TLRs) are key regulators of the innate immune system in both invertebrates and vertebrates. However, while mammalian TLRs directly recognize pathogen-associated molecular patterns, the insect Toll pathway is thought to be primarily activated by binding Spätzle cytokines that are processed from inactive precursors in response to microbial infection. Phylogenetic and structural data generated in this study supported earlier results showing that Toll9 members differ from other insect Tolls by clustering with the mammalian TLR4 group, which recognizes lipopolysaccharide (LPS) through interaction with myeloid differentiation-2 (MD-2)–like proteins. Functional experiments showed that BmToll9 from the silkmoth Bombyx mori also recognized LPS through interaction with two MD-2–like proteins, previously named BmEsr16 and BmPP, that we refer to in this study as BmMD-2A and BmMD-2B, respectively. A chimeric BmToll9–TLR4 receptor consisting of the BmToll9 ectodomain and mouse TLR4 transmembrane and Toll/interleukin-1 (TIR) domains also activated LPS-induced release of inflammatory factors in murine cells but only in the presence of BmMD-2A or BmMD-2B. Overall, our results indicate that BmToll9 is a pattern recognition receptor for LPS that shares conserved features with the mammalian TLR4–MD-2–LPS pathway.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2103021118
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2021
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  • 9
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    Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells
    Oxford University Press (OUP) ; 2023
    In:  Biology of Reproduction Vol. 108, No. 3 ( 2023-03-13), p. 504-518
    Details
    In: Biology of Reproduction, Oxford University Press (OUP), Vol. 108, No. 3 ( 2023-03-13), p. 504-518
    Abstract: The cause for at least 50% of recurrent miscarriages is unclear, which is defined as unexplained recurrent miscarriages. The B7-H1 (PD-L1), a molecule of the B7 family, promotes tumor development by modulating immune evasion, and recent researchers have also attached importance to the role of B7-H3, another molecule of B7 family, in tumor. Based on the similarity between growth and immune response in tumors and pregnancy, we first explored the role of B7-H3 in unexplained recurrent miscarriages. We found reduced levels of B7-H3 in the villus tissue of unexplained recurrent miscarriage patients, and it was mainly expressed on the cell membrane of extravillous trophoblasts. Further, the HTR-8/SVneo and JEG-3 cells were selected to explore the role of B7-H3 in proliferation, apoptosis, tube formation, migration, and invasion. We found that B7-H3 regulated trophoblast migration and invasion via RhoA/ROCK2 signaling pathway. Inflammatory cytokines were detected through enzyme-linked immunosorbent assay after co-culturing with decidual natural killer cells and B7-H3-knockout JEG-3. Results showed that B7-H3 inhibited IL-8 and IP-10 secretion from the decidual natural killer cells. In a CBA/J × DBA/2 abortion-prone mice model, treatment with B7-H3-Fc protein successfully reduced the rate of embryo resorption. In conclusion, our results revealed a possible mechanism by which decreased B7-H3 on trophoblasts of unexplained recurrent miscarriages inhibited trophoblast migration and invasion and increased IL-8 and IP-10 secretion from the decidual natural killer cells. Furthermore, B7-H3 may be a promising new therapeutic target in unexplained recurrent miscarriage patients.
    Type of Medium: Online Resource
    ISSN: 0006-3363 , 1529-7268
    URL: Article
    DOI: 10.1093/biolre/ioac220
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1469812-2
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  • 10
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    Exposure to acetamiprid influences the development and survival ability of worker bees (Apis mellifera L.) from larvae to adults
    Elsevier BV ; 2020
    In:  Environmental Pollution Vol. 266 ( 2020-11), p. 115345-
    Details
    In: Environmental Pollution, Elsevier BV, Vol. 266 ( 2020-11), p. 115345-
    Type of Medium: Online Resource
    ISSN: 0269-7491
    URL: Article
    DOI: 10.1016/j.envpol.2020.115345
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 280652-6
    detail.hit.zdb_id: 2013037-5
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    SSG: 14
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