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  • Yang, Jie  (6)
  • 2020-2024  (6)
  • 2023  (6)
  • Biodiversity Research  (6)
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  • 2020-2024  (6)
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  • 2023  (6)
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  • Biodiversity Research  (6)
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  • 1
    Online Resource
    Online Resource
    In vitro study on antitumor activity of aurantiamide acetate extracted from Polygonum capitatum
    Elsevier BV ; 2023
    In:  South African Journal of Botany Vol. 159 ( 2023-08), p. 280-289
    Details
    In: South African Journal of Botany, Elsevier BV, Vol. 159 ( 2023-08), p. 280-289
    Type of Medium: Online Resource
    ISSN: 0254-6299
    URL: Article
    DOI: 10.1016/j.sajb.2023.06.022
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2126918-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion
    MDPI AG ; 2023
    In:  Current Issues in Molecular Biology Vol. 45, No. 4 ( 2023-03-24), p. 2703-2716
    Details
    In: Current Issues in Molecular Biology, MDPI AG, Vol. 45, No. 4 ( 2023-03-24), p. 2703-2716
    Abstract: Rosacea is a chronic inflammatory skin disease whose late manifestations have not yet been clearly reported in animal models. The objective of this study is to describe the skin lesions and major histopathological changes in a rosacea-like phenotype in mice induced by prolonged LL-37 administration and furthermore, to assess the potential of long-term LL-37 administration in inducing irreversible rosacea-like skin lesion models. Balb/c mice were continuously injected intradermally with LL-37 every 12 h to induce a rosacea-like phenotype. After LL-37 injections were administered for 20 consecutive days, the area of rosacea-like lesions gradually expanded in the first 13 days, then entered a stable phase. Haematoxylin and eosin (H & E) and Van Gieson’s staining showed a high degree of inflammatory cell aggregation, thickening of the epidermis and dermis, and collagen deposition in large quantities. The results of immunofluorescence staining and Western blotting showed that the expression of α-SMA, TNF-α, vimentin, and COL1 in the skin of mice was significantly upregulated. Short-term LL-37 administration induced rosacea-like lesions that only featured the aggregation of inflammatory factors and thickening of the epidermis, whereas no collagen hyperplasia was observed, and a full recovery was noticed. However, rosacea-like skin lesions induced by long-term LL-37 administration did not completely recover. Our study compares rosacea-like lesions induced by short-term versus long-term LL-37 administration, and the results suggest that irreversible rosacea-like lesions can be induced by long-term LL-37 administration.
    Type of Medium: Online Resource
    ISSN: 1467-3045
    URL: Article
    DOI: 10.3390/cimb45040177
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2090836-2
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Structures and implications of the C962R protein of African swine fever virus
    Oxford University Press (OUP) ; 2023
    In:  Nucleic Acids Research Vol. 51, No. 17 ( 2023-09-22), p. 9475-9490
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 51, No. 17 ( 2023-09-22), p. 9475-9490
    Abstract: African swine fever virus (ASFV) is highly contagious and can cause lethal disease in pigs. Although it has been extensively studied in the past, no vaccine or other useful treatment against ASFV is available. The genome of ASFV encodes more than 170 proteins, but the structures and functions for the majority of the proteins remain elusive, which hindered our understanding on the life cycle of ASFV and the development of ASFV-specific inhibitors. Here, we report the structural and biochemical studies of the highly conserved C962R protein of ASFV, showing that C962R is a multidomain protein. The N-terminal AEP domain is responsible for the DNA polymerization activity, whereas the DNA unwinding activity is catalyzed by the central SF3 helicase domain. The middle PriCT2 and D5_N domains and the C-terminal Tail domain all contribute to the DNA unwinding activity of C962R. C962R preferentially works on forked DNA, and likely functions in Base-excision repair (BER) or other repair pathway in ASFV. Although it is not essential for the replication of ASFV, C962R can serve as a model and provide mechanistic insight into the replicative primase proteins from many other species, such as nitratiruptor phage NrS-1, vaccinia virus (VACV) and other viruses.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkad677
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Crystal structures and identification of novel Cd2+-specific DNA aptamer
    Oxford University Press (OUP) ; 2023
    In:  Nucleic Acids Research Vol. 51, No. 9 ( 2023-05-22), p. 4625-4636
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 51, No. 9 ( 2023-05-22), p. 4625-4636
    Abstract: Cadmium (Cd) is one of the most toxic heavy metals. Exposure to Cd can impair the functions of the kidney, respiratory system, reproductive system and skeletal system. Cd2+-binding aptamers have been extensively utilized in the development of Cd2+-detecting devices; however, the underlying mechanisms remain elusive. This study reports four Cd2+-bound DNA aptamer structures, representing the only Cd2+-specific aptamer structures available to date. In all the structures, the Cd2+-binding loop (CBL-loop) adopts a compact, double-twisted conformation and the Cd2+ ion is mainly coordinated with the G9, C12 and G16 nucleotides. Moreover, T11 and A15 within the CBL-loop form one regular Watson–Crick pair and stabilize the conformation of G9. The conformation of G16 is stabilized by the G8–C18 pair of the stem. By folding and/or stabilizing the CBL-loop, the other four nucleotides of the CBL-loop also play important roles in Cd2+ binding. Similarly to the native sequence, crystal structures, circular dichroism spectrum and isothermal titration calorimetry analysis confirm that several variants of the aptamer can recognize Cd2+. This study not only reveals the underlying basis for the binding of Cd2+ ions with the aptamer, but also extends the sequence for the construction of novel metal–DNA complex.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkad239
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    A point-of-care microfluidic biosensing system for rapid and ultrasensitive nucleic acid detection from clinical samples
    Royal Society of Chemistry (RSC) ; 2023
    In:  Lab on a Chip Vol. 23, No. 17 ( 2023), p. 3862-3873
    Details
    In: Lab on a Chip, Royal Society of Chemistry (RSC), Vol. 23, No. 17 ( 2023), p. 3862-3873
    Abstract: Rapid and ultrasensitive point-of-care RNA detection plays a critical role in the diagnosis and management of various infectious diseases. The gold-standard detection method of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is ultrasensitive and accurate yet limited by the lengthy turnaround time (1–2 days). On the other hand, an antigen test offers rapid at-home detection (typically ~15 min) but suffers from low sensitivity and high false-negative rates. An ideal point-of-care diagnostic device would combine the merits of PCR-level sensitivity and rapid sample-to-result workflow comparable to antigen testing. However, the existing detection platforms typically possess superior sensitivity or rapid sample-to-result time, but not both. This paper reports a point-of-care microfluidic device that offers ultrasensitive yet rapid detection of viral RNA from clinical samples. The device consists of a microfluidic chip for precisely manipulating small volumes of samples, a miniaturized heater for viral lysis and ribonuclease inactivation, a Cas13a-electrochemical sensor for target preamplification-free and ultrasensitive RNA detection, and a smartphone-compatible potentiostat for data acquisition. As demonstrations, the devices achieve the detection of heat-inactivated SARS-CoV-2 samples with a limit of detection down to 10 aM within 25 minutes, which is comparable to the sensitivity of RT-PCR and rapidness of an antigen test. The platform also successfully distinguishes all nine positive unprocessed clinical SARS-CoV-2 nasopharyngeal swab samples from four negative samples within 25 minutes of sample-to-result time. Together, this device provides a point-of-care solution that can be deployed in diverse settings beyond laboratory environments for rapid and accurate detection of RNA from clinical samples. The device can potentially be expandable to detect other viral targets, such as human immunodeficiency virus self-testing and Zika virus, where rapid and ultrasensitive point-of-care detection is required.
    Type of Medium: Online Resource
    ISSN: 1473-0197 , 1473-0189
    URL: Article
    DOI: 10.1039/D3LC00372H
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2056646-3
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6–miR449c-5p–PIGV axis
    Elsevier BV ; 2023
    In:  Journal of Biological Chemistry Vol. 299, No. 8 ( 2023-08), p. 104982-
    Details
    In: Journal of Biological Chemistry, Elsevier BV, Vol. 299, No. 8 ( 2023-08), p. 104982-
    Type of Medium: Online Resource
    ISSN: 0021-9258
    URL: Article
    DOI: 10.1016/j.jbc.2023.104982
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2141744-1
    detail.hit.zdb_id: 1474604-9
    SSG: 12
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