In:
Bioscience, Biotechnology, and Biochemistry, Oxford University Press (OUP), ( 2024-02-09)
Abstract:
A new lipopeptide, N-desmethylmajusculamide B (1), was isolated from the Okinawan cyanobacterium Okeania hirsuta along with two known compounds majusculamide A (2) and majusculamide B (3). The planar structure of 1 was elucidated by a detailed analysis of MS and NMR spectra. The absolute configurations of the amino acid residues were determined using Marfey's analysis. The configuration of C-16 in the α-methyl-β-keto-decanoyl moiety was determined unambiguously to be S by conducting a semi-synthesis of N-desmethylmajusculamide B from 3. The cytotoxicity against mouse L1210 leukemia cells was evaluated for majusculamides (1-3).
Type of Medium:
Online Resource
ISSN:
1347-6947
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
2110940-0
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