In:
The EMBO Journal, EMBO, Vol. 42, No. 14 ( 2023-07-17)
Abstract:
image The facultative intracellular pathogen Brucella abortus forms a replicative niche in the endoplasmic reticulum and hijacks the autophagic machinery for its egress from the host cell. This study shows that B. abortus induces BNIP3L‐mediated mitophagy, which is required for bacterial egress and infection of neighbouring cells. B. abortus triggers BNIP3L‐mediated mitophagy during the late steps of cellular infection. B. abortus induces BNIP3L expression in a manner dependent on iron and HIF‐1α stabilization. Iron and BNIP3L‐mediated mitophagy are required for bacterial egress from host cells. B. abortus are found inside mitochondria of HeLa cells and immortalized bone marrow‐derived macrophages.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022112817
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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