In:
International Journal of Developmental Neuroscience, Wiley, Vol. 4, No. 6 ( 1986-01), p. 497-501
Abstract:
The effects of perinatal exposure to soy lecithin preparation (SLP) on the development of cholinergic responses in the rat brain were examined by assessing the ability of intracisternally administered carbachol to stimulate 33 Pi incorporation into phospholipids in vivo , an effect of carbachol mediated by muscarinic cholinergic receptors. Maternal intake of SLP produced a suppression of the cholinergic response in the offspring, an effect which was specific in that basal (unstimulated) incorporation rates were not reduced (in fact, they eventually became elevated), nor was the response to another neurotransmitter (dopamine) compromised. The effect occurred early in the preweanling stage, a period in which SLP exposure also enhances development of cholinergic nerve terminals. These results suggest that SLP exposure has a major effect on cholinergic synaptic development and reactivity, followed by secondary changes in other neurotransmitter pathways and by more generalized effects on basal membrane phospholipid turnover.
Type of Medium:
Online Resource
ISSN:
0736-5748
,
1873-474X
DOI:
10.1016/0736-5748(86)90001-8
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
2012538-0
detail.hit.zdb_id:
2013748-5
SSG:
12
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