In:
Chemistry & Biodiversity, Wiley, Vol. 9, No. 9 ( 2012-09), p. 1840-1848
Abstract:
A series of eight novel diamminetetrakis(carboxylato)platinum(IV) complexes was synthesized and characterized by multinuclear 1 H‐, 13 C‐, 15 N‐, and 195 Pt‐NMR spectroscopy. Their antiproliferative potency was evaluated in three human cancer cell lines representing ovarian (CH1), lung (A549), and colon carcinoma (SW480). In cisplatin‐sensitive CH1 cancer cells, cytotoxicity was found in the low micromolar range, whereas, in inherently cisplatin‐resistant A549 and SW480 cells, the activity was very low or negligible. Astonishingly, raise in lipophilicity of the complexes, as found in the case of cisplatin analogs, did not result in a significant enhancement of the cytotoxic effect.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201200019
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2139001-0
SSG:
12
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