In:
Chemistry & Biodiversity, Wiley, Vol. 13, No. 12 ( 2016-12), p. 1738-1746
Abstract:
Four new tirucallane triterpenoids, (21 S ,23 R ,24 R )‐21,23‐epoxy‐21,24‐dihydroxy‐25‐methoxytirucall‐7‐en‐3‐one ( 2 ), (3 S ,21 S ,23 R ,24 S )‐21,23‐epoxy‐21,25‐dimethoxytirucall‐7‐ene‐3,24‐diol ( 8 ), (21 S ,23 R ,24 R )‐21,23‐epoxy‐24‐hydroxy‐21‐methoxytirucalla‐7,25‐dien‐3‐one ( 11 ), and (21 S ,23 R ,24 R )‐21,23‐epoxy‐21,24‐dihydroxytirucalla‐7,25‐dien‐3‐one ( 12 ), along with 16 known analogues, 1 , 3 – 7 , 9 – 10 , and 13 – 20 , were isolated from the fruits of Melia azedarach . Their structures were elucidated by spectroscopic methods including 1D‐ and 2D‐ NMR techniques and mass spectrometry. These compounds were evaluated for their cytotoxicities against HepG2 (liver), SGC 7901 (stomach), K562 (leukemia), and HL 60 (leukemia) cancer cell lines. Compound 20 exhibited potent cytotoxicity against HepG2 and SGC 7901 cancer cells with the IC 50 values of 6.9 and 6.9 μ m , respectively.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201600149
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2139001-0
SSG:
12
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