In:
BIOspektrum, Springer Science and Business Media LLC, Vol. 27, No. 4 ( 2021-06), p. 368-371
Abstract:
The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host’s antiviral immune response.
Type of Medium:
Online Resource
ISSN:
0947-0867
,
1868-6249
DOI:
10.1007/s12268-021-1595-3
Language:
German
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
1236314-5
detail.hit.zdb_id:
2203536-9
SSG:
12
SSG:
15,3
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