In:
Chinese Journal of Chemistry, Wiley, Vol. 30, No. 12 ( 2012-12), p. 2767-2773
Abstract:
The gem ‐difluoromethylenated acetonide 2 was efficiently synthesized as new precursor of HMG‐CoA reductase inhibitor. Straightforward olefination via Pd‐catalyzed C 4 ‐H activation of 1,3,5‐trisubstituted pyrazoles 1 was proceeded smoothly in the presence of Pd(OAc) 2 and AgCO 3 . This protocol has merits in terms of the improved atomic economy and prevention from the generation of by‐products.
Type of Medium:
Online Resource
ISSN:
1001-604X
,
1614-7065
DOI:
10.1002/cjoc.201201100
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2144352-X
SSG:
6,25
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