In:
Chinese Journal of Chemistry, Wiley, Vol. 35, No. 8 ( 2017-08), p. 1231-1238
Abstract:
The double Michael reactions between benzofuran‐3‐one or 1‐indone and symmetric dienones in the presence of catalytic ionic liquids were successfully developed and spiro[benzofuran‐2,1’‐cyclohexane]‐3‐one or spiro[cyclohexane‐1,2’‐indene] ‐1’,4(3’ H )‐dione derivatives containing a spiro quaternary stereogenic center, which widely exist in biologically active products and building blocks in organic synthesis, were obtained in excellent yields (up to 99%). This catalytic system was also extended to the double Michael reaction of less reactive 1‐indone and the desired products were also obtained in 31%‐62% yields. The catalytic system was highly active and efficient for a broad of substrates under mild conditions.
Type of Medium:
Online Resource
ISSN:
1001-604X
,
1614-7065
DOI:
10.1002/cjoc.201600796
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2144352-X
SSG:
6,25
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