In:
Chinese Journal of Chemistry, Wiley, Vol. 41, No. 10 ( 2023-05-15), p. 1209-1225
Abstract:
In this study, 27 new sesquiterpenoids: twenty monomers and seven dimers, with diverse structures, along with one known chlorajaponilide F ( 25 ) were isolated from the aerial parts of Chloranthus henryi var. hupehensis. Structurally, chlorahupetolides A ( 1 ) and B ( 2 ), two eudesmane‐type merosesquiterpenoids with an undescribed C 18 carbon framework, and chlorahupetene E ( 18 ) are the first example of dimers comprising two eudesmane sesquiterpenoids bridged by a four‐membered ring in the Chloranthus . Their structures were characterized by nuclear magnetic resonance (NMR), electronic circular dichroism (ECD), and X‐ray diffraction analysis. In the RAW264.7 macrophages model of inflammation induced by LPS, compounds 12 , 18 , and 25 significantly reduced NO production in a dose dependent manner and without cytotoxicity. The mRNA expression of COX‐2 was considerably inhibited by treatments with compounds 12 , 18 , and 25 .
Type of Medium:
Online Resource
ISSN:
1001-604X
,
1614-7065
DOI:
10.1002/cjoc.202200824
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2144352-X
SSG:
6,25
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