In:
Chinese Journal of Chemistry, Wiley, Vol. 30, No. 6 ( 2012-06), p. 1226-1230
Abstract:
Four new ent ‐kaurane diterpenoids, 6 β ,13 α ,15 β ‐trihydroxy‐16‐ene‐3 α ,20‐epoxy‐ ent ‐kaur‐1,7‐dione ( 1 ), 6‐hydroxy‐3 α ,20‐epoxy‐5(6)‐ene‐ ent ‐kaur‐1,7,15‐trione ( 2 ), 6‐hydroxy‐15 β ‐acetoxy‐3 α ,20‐epoxy‐16 β ,17‐epoxy‐5(6)‐ene‐ ent ‐kaur‐1,7‐dione ( 3 ), 3 α ,17‐dihydroxy‐15(16)‐ene‐ ent ‐kaur‐7‐one ( 4 ), along with four known compounds 5 – 8 were isolated from the leaves of Isodon eriocalyx var . laxiflora. The structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR). The cytotoxic activities of these compounds were evaluated by MTT assay. Compound 8 showed moderate inhibitory effects on HL‐60, SMMC‐7721, MCF‐7 and SW‐480 cell lines.
Type of Medium:
Online Resource
ISSN:
1001-604X
,
1614-7065
DOI:
10.1002/cjoc.201100653
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2144352-X
SSG:
6,25
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