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  • Online-Ressource  (16)
  • Wiley  (16)
  • Asien - CrossAsia  (16)
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  • Online-Ressource  (16)
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  • Wiley  (16)
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  • 1
    Online-Ressource
    Online-Ressource
    11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6)
    Wiley ; 2018
    In:  Chinese Journal of Chemistry Vol. 36, No. 12 ( 2018-12), p. 1197-1201
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 36, No. 12 ( 2018-12), p. 1197-1201
    Kurzfassung: Artemisinin (Qinghaosu), a sesquiterpene lactone isolated from the Chinese medicinal herb Artemisia annua , is famous as the first‐line antimalarial drug, and reported to also possess anticancer properties. Though many studies have proceeded focusing on artemisinin and bioactive derivatives in clinic or laboratory, their cellular targets and mechanism of actions have still remained obscure. Here, two new 11‐aza‐artemisinin derivatives AAD1 and AAD2, which displayed cytotoxity against multiple cancer cell lines, were synthesized and applied as the probes for target identification and anticancer mechanism research. Using T7 phage display screen method, fatty acid binding protein 6 (FABP6) was identified and verified as one of the potential targets. Further studies showed FABP6 is a direct binding protein of AAD1 and AAD2, and mediated the corresponding anticancer activities of these artemisinin derivatives.
    Materialart: Online-Ressource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v36.12
    DOI: 10.1002/cjoc.201800361
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2144352-X
    SSG: 6,25
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  • 2
    Online-Ressource
    Online-Ressource
    One-pot Synthesis of Bis(dihydropyrimidinone-4-yl)benzene Using Boric Acid as a Catalyst
    Wiley ; 2005
    In:  Chinese Journal of Chemistry Vol. 23, No. 5 ( 2005-05), p. 596-598
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 23, No. 5 ( 2005-05), p. 596-598
    Materialart: Online-Ressource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/cjoc.v23:5
    DOI: 10.1002/(ISSN)1614-7065
    DOI: 10.1002/cjoc.200590596
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2005
    ZDB Id: 2144352-X
    SSG: 6,25
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  • 3
    Online-Ressource
    Online-Ressource
    The Tree of Life: China project
    Wiley ; 2016
    In:  Journal of Systematics and Evolution Vol. 54, No. 4 ( 2016-07), p. 273-276
    Details
    In: Journal of Systematics and Evolution, Wiley, Vol. 54, No. 4 ( 2016-07), p. 273-276
    Materialart: Online-Ressource
    ISSN: 1674-4918 , 1759-6831
    URL: Issue
    URL: Article
    DOI: 10.1111/jse.v54.4
    DOI: 10.1111/jse.12215
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 2516638-4
    SSG: 6,25
    SSG: 12
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  • 4
    Online-Ressource
    Online-Ressource
    Functional consequences of temporal reversal of height dimorphism for pollen and seed dispersal in a dioecious plant
    Wiley ; 2023
    In:  Journal of Systematics and Evolution
    Details
    In: Journal of Systematics and Evolution, Wiley
    Kurzfassung: The adaptive significance of phenotypic differences between females and males can provide insights into sex‐specific selection and the evolution of sexual dimorphism. Dioecious plants commonly exhibit sexual dimorphism in height, although its ecological and evolutionary significance have rarely been examined experimentally. Here, we investigate the functional consequences of the temporal reversal of height dimorphism for pollen and seed dispersal in dioecious Rumex hastatulus Baldw., a species in which males are taller than females at flowering and the reverse pattern occurs at fruiting. Populations of this colonizing weed are wind‐pollinated and seeds are wind‐dispersed. In a glasshouse experiment we manipulated the height of pollen donors and using sex‐specific genetic markers compared the paternal success of males of contrasting height and investigated whether seed families showed evidence of sexual dimorphism in early life‐history traits. In a second glasshouse experiment using fruiting plants we also examined how female height influenced the distance that seeds were dispersed. We found that taller males had significantly higher siring success than males of equivalent height to flowering females. Similarly, taller females dispersed fruit to greater distances than shorter females. Female seeds were significantly heavier than male seeds and germinated more rapidly, although early seedling growth was greater in males. Our study suggests that the striking sex reversal of height in R. hastatulus likely functions to optimize the contrasting reproductive functions of the sexes by promoting increased pollen and seed dispersal distances. Improved dispersal quality could limit inbreeding and reduce local mate and resource competition within populations.
    Materialart: Online-Ressource
    ISSN: 1674-4918 , 1759-6831
    URL: Article
    DOI: 10.1111/jse.12960
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2516638-4
    SSG: 6,25
    SSG: 12
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  • 5
    Online-Ressource
    Online-Ressource
    Northern gene flow into southeastern East Asians inferred from genome‐wide array genotyping
    Wiley ; 2023
    In:  Journal of Systematics and Evolution Vol. 61, No. 1 ( 2023-01), p. 179-197
    Details
    In: Journal of Systematics and Evolution, Wiley, Vol. 61, No. 1 ( 2023-01), p. 179-197
    Kurzfassung: The population history of Southeast (SE) China remains poorly understood due to the sparse sampling of present‐day populations and limited modeling with ancient genomic data. We report genome‐wide genotyping data from 207 present‐day Han Chinese and Hmong‐Mien (HM)‐speaking She people from Fujian and Taiwan Island, SE China. We coanalyzed 66 Early Neolithic to Iron Age ancient Fujian and Taiwan Island individuals obtained from previously published works to explore the genetic continuity and admixture based on patterns of genetic variations of the high‐resolution time transect. We found the genetic differentiation between northern and southern East Asians was defined by a north–south East Asian genetic cline and our studied southern East Asians were clustered in the southern end of this cline. The southeastern coastal modern East Asians are genetically similar to other southern indigenous groups as well as geographically close to Neolithic‐to‐Iron Age populations, but they also shared excess alleles with post‐Neolithic Yellow River ancients, which suggested a southward gene flow on the modern southern coastal gene pool. In addition, we identified one new HM genetic cline in East Asia with the coastal Fujian HM‐speaking She localizing at the intersection between HM and Han clines. She people show stronger genetic affinity with southern East Asian indigenous populations, with the main ancestry deriving from groups related to southeastern ancient indigenous rice farmers. The southeastern Han Chinese could be modeled with the primary ancestry deriving from the group related to the Yellow River Basin millet farmers and the remaining from groups related to rice farmers, which was consistent with the northern China origin of modern southeastern Han Chinese and in line with the historically and archaeologically attested southward migrations of Han people and their ancestors. Our estimated north–south admixture time ranges based on the decay of the linkage disequilibrium spanned from the Bronze Age to historic periods, suggesting the recent large‐scale population migrations and subsequent admixture participated in the formation of modern Han in SE Asia.
    Materialart: Online-Ressource
    ISSN: 1674-4918 , 1759-6831
    URL: Issue
    URL: Article
    DOI: 10.1111/jse.v61.1
    DOI: 10.1111/jse.12826
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2516638-4
    SSG: 6,25
    SSG: 12
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  • 6
    Online-Ressource
    Online-Ressource
    Mitochondrial genes from 18 angiosperms fill sampling gaps for phylogenomic inferences of the early diversification of flowering plants
    Wiley ; 2022
    In:  Journal of Systematics and Evolution Vol. 60, No. 4 ( 2022-07), p. 773-788
    Details
    In: Journal of Systematics and Evolution, Wiley, Vol. 60, No. 4 ( 2022-07), p. 773-788
    Kurzfassung: The early diversification of angiosperms is thought to have been a rapid process, which may complicate phylogenetic analyses of early angiosperm relationships. Plastid and nuclear phylogenomic studies have raised several conflicting hypotheses regarding overall angiosperm phylogeny, but mitochondrial genomes have been largely ignored as a relevant source of information. Here we sequenced mitochondrial genomes from 18 angiosperms to fill taxon‐sampling gaps in Austrobaileyales, magnoliids, Chloranthales, Ceratophyllales, and major lineages of eudicots and monocots. We assembled a data matrix of 38 mitochondrial genes from 107 taxa to assess how well mitochondrial genomic data address current uncertainties in angiosperm relationships. Although we recovered conflicting phylogenies based on different data sets and analytical methods, we also observed congruence regarding deep relationships of several major angiosperm lineages: Chloranthales were always inferred to be the sister group of Ceratophyllales, Austrobaileyales to mesangiosperms, and the unplaced Dilleniales was consistently resolved as the sister to superasterids. Substitutional saturation, GC compositional heterogeneity, and codon‐usage bias are possible reasons for the noise/conflict that may impact phylogenetic reconstruction; and angiosperm mitochondrial genes may not be substantially affected by these factors. The third codon positions of the mitochondrial genes appear to contain more parsimony‐informative sites than the first and second codon positions, and therefore produced better resolved phylogenetic relationships with generally strong support. The relationships among these major lineages remain incompletely resolved, perhaps as a result of the rapidity of early radiations. Nevertheless, data from mitochondrial genomes provide additional evidence and alternative hypotheses for exploring the early evolution and diversification of the angiosperms.
    Materialart: Online-Ressource
    ISSN: 1674-4918 , 1759-6831
    URL: Issue
    URL: Article
    DOI: 10.1111/jse.v60.4
    DOI: 10.1111/jse.12708
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2516638-4
    SSG: 6,25
    SSG: 12
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  • 7
    Online-Ressource
    Online-Ressource
    Ancient genome of Empress Ashina reveals the Northeast Asian origin of Göktürk Khanate
    Wiley ; 2023
    In:  Journal of Systematics and Evolution
    Details
    In: Journal of Systematics and Evolution, Wiley
    Materialart: Online-Ressource
    ISSN: 1674-4918 , 1759-6831
    URL: Article
    DOI: 10.1111/jse.12938
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2516638-4
    SSG: 6,25
    SSG: 12
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  • 8
    Online-Ressource
    Online-Ressource
    Discovery and Geological Significance of Neoproterozoic Metamorphic Granite in Jimo, Shandong Province, Eastern China
    Wiley ; 2016
    In:  Acta Geologica Sinica - English Edition Vol. 90, No. 6 ( 2016-12), p. 2080-2096
    Details
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 90, No. 6 ( 2016-12), p. 2080-2096
    Kurzfassung: During the 1:50000 regional geological survey in Jimo, east Shandong Province, Paleoproterozoic metamorphic supracrustal rocks and Neoproterozoic metamorphic plutonite were newly discovered. These rocks displayed inclusions which had occurred in the Mesozoic granite, and the main lithologies are schist, granulite, marble, and granitic gneiss. Geochemical analyses suggest that Neoproterozoic metamorphic plutonite are characterized by high‐K, metaluminous to weakly peraluminous. They are enriched in LILE and depleted in HFSE, with moderately enrichment of LREE, weak fractionation of LREE from HREE and negative Eu anomalies. The surface age of plutonic rocks in the survey area is 770.2±2.4 Ma, representing the age of magma crystallization, which is agreement with the the Neoproterozoic magmatic event after Rodinia supercontinent in the northern margin of Southern China continental block. In addition, the age of sporadic distribution (298 Ma and 269 Ma) is mixed zircon age, representing the rocks experienced metamorphism in Indosinian period. According to the associated mineral assemblages, and the characteristic metamorphic minerals and temperature pressure conditions, four metamorphic facies were identified, including amphibolitic, epidote amphibolite, greenschist, and mid‐high pressure greenschist. Analysis of tectonic setting suggests that granitic gneiss is formed in an extensional environment and was involved from the continental margin magmatic arc to intraplate environment. Jimo is distributed in the east of Zhuwu fault, and has the same Spatial distribution location with the Weihai uplift UHP metamorphic belt rocks. The metamorphic rocks in Jimo area have similar geochemical characteristics of elements, tectonic setting and retrograde metamorphism with that in the Sulu UHP metamorphic belt. Therefore, Zhuwu fault may be the boundary fault of Sulu UHP metamorphic belt.
    Materialart: Online-Ressource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    URL: Article
    DOI: 10.1111/acgs.2016.90.issue-6
    DOI: 10.1111/1755-6724.13023
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 2420386-5
    SSG: 6,25
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  • 9
    Online-Ressource
    Online-Ressource
    2D NMR ‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids †
    Wiley ; 2022
    In:  Chinese Journal of Chemistry Vol. 40, No. 18 ( 2022-09-15), p. 2169-2178
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 40, No. 18 ( 2022-09-15), p. 2169-2178
    Kurzfassung: The tribe Delphineae, comprising two genera, Aconitum L. and Delphinium L., is the richest source of bioactive diterpenoid alkaloids (DAs), while their highly similar chemical structures create a major challenge for dereplication from complex mixture. To solve the inefficient discovery process of natural DAs, a novel dereplication strategy based on pattern recognition of specific heteronuclear multiple bond correlation (HMBC) signals has been established in this study. This strategy utilized the diagnostic signals in the HMBC spectra of C 19 ‐DAs, which could indicate the structural categories. The newly designed software MatchNat allowed in silico recognition of C 19 ‐DA types. The developed dereplication system was demonstrated to be a practical strategy to dereplicate a variety of natural products from two Delphineae plants, including Aconitum vilmorinianum Kom. and Delphinium pachycentrum Hemsl. Known compounds could be rapidly recognized from the mixture, and novel DAs were found with the aid of MatchNat. Consequently, targeted isolation led to the explosive discovery of a series of novel DAs. This dereplication system has the potential to be adopted for dereplication of any other class of natural products and has shown promising application as a complementary tool in the nuclear magnetic resonance analysis of traditional Chinese medicines.
    Materialart: Online-Ressource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v40.18
    DOI: 10.1002/cjoc.202200250
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2144352-X
    SSG: 6,25
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  • 10
    Online-Ressource
    Online-Ressource
    Dcalycinumines A–E, alkaloids with cytotoxic activities of nasopharyngeal carcinoma cells from Daphniphyllum calycinum
    Wiley ; 2023
    In:  Chinese Journal of Chemistry
    Details
    In: Chinese Journal of Chemistry, Wiley
    Kurzfassung: Five novel Daphniphyllum alkaloids, named dcalycinumines A–E ( 1 – 4 , 6 ), and eight previously described Daphniphyllum alkaloids ( 5 , 7 – 13 ) were isolated from Daphniphyllum calycinum . Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3‐methyl‐1‐azabicyclo [4,4,0] decane ring system. Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1‐aza‐6‐azaspiro [4,5] decane unit, whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2 . Compound 4 is the second example of C‐22‐nor yuzurimine‐type alkaloids. Their structures and absolute configurations were elucidated by HRESIMS, NMR spectroscopic analyses, ECD calculations, and single‐crystal X‐ray diffraction. Moreover, compound 1 showed remarkable antitumor activities, which could inhibit the proliferation, migration and invasion of nasopharyngeal carcinoma cells, and promoted nasopharyngeal carcinoma cells apoptosis. This article is protected by copyright. All rights reserved.
    Materialart: Online-Ressource
    ISSN: 1001-604X , 1614-7065
    URL: Article
    DOI: 10.1002/cjoc.202300442
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2144352-X
    SSG: 6,25
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