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  • Ovid Technologies (Wolters Kluwer Health)  (19)
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  • Asia - CrossAsia  (19)
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  • Ovid Technologies (Wolters Kluwer Health)  (19)
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  • Asia - CrossAsia  (19)
  • 1
    Online Resource
    Online Resource
    Optimized cutoff maternal age for adverse obstetrical outcomes: a multicenter retrospective cohort study in Urban China during 2011 to 2012
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 3 ( 2020-01-13), p. 269-276
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 3 ( 2020-01-13), p. 269-276
    Abstract: China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. Methods: This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China during 2011 to 2012. Logistic regression was used to assess the adjusted odds ratios (aOR) of adverse outcomes in different age groups in comparison to women aged 20 to 24 years. The adjustments included the location of the hospital, educational level, and residence status. Clinically cutoff age was defined as the age above which the aOR continuously become both statistically ( P   〈  0.05) and clinically (aOR  〉  2) significant. Results: Overall, 108,059 women were recruited. In primiparae, clinically cutoff maternal ages for gestational diabetes (aOR: 2.136, 95% confidence interval [CI]: 1.856–2.458, P   〈  0.001), placenta previa (aOR: 2.400, 95% CI: 1.863–3.090, P   〈  0.001), cesarean section (aOR: 2.511, 95% CI: 2.341–2.694, P   〈  0.001), hypertensive disorder (aOR: 2.122, 95% CI: 1.753–2.569, P   〈  0.001), post-partum hemorrhage (aOR: 2.129, 95% CI: 1.334–3.397, P   〈  0.001), and low birth weight (aOR: 2.174, 95% CI: 1.615–2.927, P   〈  0.001) were 27, 31, 33, 37, 41, and 41 years, respectively. In multiparae, clinically cutoff ages for gestational diabetes (aOR: 2.977, 95%CI: 1.808–4.904, P   〈  0.001), hypertensive disorder (aOR: 2.555, 95% CI: 1.836–3.554, P   〈  0.001), cesarean section (aOR: 2.224, 95% CI: 1.952–2.534, P   〈  0.001), post-partum hemorrhage (aOR: 2.140, 95% CI: 1.472–3.110, P   〈  0.001), placenta previa (aOR: 2.272, 95% CI: 1.375–3.756, P   〈  0.001), macrosomia (aOR: 2.215, 95% CI: 1.552–3.161, P   〈  0.001), and neonatal asphyxia (aOR: 2.132, 95% CI: 1.461–3.110, P   〈  0.001) were 29, 31, 33, 35, 35, 41, and 41 years, respectively. Conclusions: Early cutoff ages for gestational diabetes and cesarean section highlight a reasonable childbearing age in urban China. The various optimized cutoff ages for different adverse pregnancy outcomes should be carefully considered in childbearing women.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000000626
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    Critical hubs of renal ischemia-reperfusion injury: endoplasmic reticulum-mitochondria tethering complexes
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 21 ( 2020-09-21), p. 2599-2609
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 21 ( 2020-09-21), p. 2599-2609
    Abstract: Mitochondrial injury and endoplasmic reticulum (ER) stress are considered to be the key mechanisms of renal ischemia-reperfusion (I/R) injury. Mitochondria are membrane-bound organelles that form close physical contact with a specific domain of the ER, known as mitochondrial-associated membranes. The close physical contact between them is mainly restrained by ER-mitochondria tethering complexes, which can play an important role in mitochondrial damage, ER stress, lipid homeostasis, and cell death. Several ER-mitochondria tethering complex components are involved in the process of renal I/R injury. A better understanding of the physical and functional interaction between ER and mitochondria is helpful to further clarify the mechanism of renal I/R injury and provide potential therapeutic targets. In this review, we aim to describe the structure of the tethering complex and elucidate its pivotal role in renal I/R injury by summarizing its role in many important mechanisms, such as mitophagy, mitochondrial fission, mitochondrial fusion, apoptosis and necrosis, ER stress, mitochondrial substance transport, and lipid metabolism.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001091
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
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  • 3
    Online Resource
    Online Resource
    Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Chinese Medical Journal
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health)
    Abstract: Disease-modifying therapies have been approved for the treatment of relapsing multiple sclerosis (RMS). The present study aims to examine the safety of teriflunomide in Chinese patients with RMS. Methods: This non-randomized, multi-center, 24-week, prospective study enrolled RMS patients with variant (c.421C 〉 A) or wild type ABCG2 who received once-daily oral teriflunomide 14 mg. The primary endpoint was the relationship between ABCG2 polymorphisms and teriflunomide exposure over 24 weeks. Safety was assessed over the 24-week treatment with teriflunomide. Results: Eighty-two patients were assigned to variant ( n = 42) and wild type groups ( n = 40), respectively. Geometric mean and geometric standard deviation (SD) of pre-dose concentration (variant, 54.9 [38.0] μg/mL; wild type, 49.1 [32.0] μg/mL) and area under plasma concentration-time curve over a dosing interval (AUC tau ) (variant, 1731.3 [769.0] μg∙h/mL; wild type, 1564.5 [1053.0] μg∙h/mL) values at steady state were approximately similar between the two groups. Safety profile was similar and well tolerated across variant and wild type groups in terms of rates of treatment emergent adverse events (TEAE), treatment-related TEAE, grade ≥3 TEAE, and serious adverse events (AEs). No new specific safety concerns or deaths were reported in the study. Conclusion: ABCG2 polymorphisms did not affect the steady-state exposure of teriflunomide, suggesting a similar efficacy and safety profile between variant and wild type RMS patients. Registration: NCT04410965, https://clinicaltrials.gov.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000002990
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2108782-9
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  • 4
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    Online Resource
    Increased early activation of CD56dimCD16dim/- natural killer cells in immunological non-responders correlates with CD4+ T-cell recovery
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 24 ( 2020-11-25), p. 2928-2939
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 24 ( 2020-11-25), p. 2928-2939
    Abstract: Natural killer (NK) cells play a critical role in suppressing human immunodeficiency virus-1 (HIV-1) infection, but knowledge on whether and how NK cells affect immune reconstitution in HIV-1-infected individuals who receive antiretroviral therapy (ART) is limited. Methods We performed a case-control study with 35 healthy individuals and 66 HIV-1-infected patients including 32 immunological non-responders (INRs) with poor CD4 + T-cell recovery ( 〈 500 cells/μL after 4 years of ART) and 34 immunological responders (IRs) with improved CD4 + T-cell recovery ( 〉 500 cells/μL after 4 years of ART). NK cell phenotype, receptor repertoire, and early activation in INRs and IRs were investigated by flow cytometry. Results A significantly higher proportion of CD56 dim CD16 dim/- NK cells was observed in INRs than IRs before ART and after 4 years of ART. The number of CD56 dim CD16 dim/- NK cells was inversely correlated with CD4 + T-cell counts in INRs before ART ( r  = –0.344, P  = 0.050). The more CD69-expressing NK cells there were, the lower the CD4 + T-cell counts and ΔCD4, and these correlations were observed in INRs after ART ( r  = –0.416, P  = 0.019; r  = –0.509, P  = 0.003, respectively). Additionally, CD69-expressing CD56 dim CD16 dim/- NK cells were more abundant in INRs than those in IRs ( P   =  0.018) after ART, both of which had an inverse association trend towards significance with CD4 + T-cell counts. The expression of the activating receptors NKG2C, NKG2D, and NKp46 on CD56 dim CD16 dim/- NK cell subsets were higher in IRs than that in INRs after 4 years of ART (all P   〈  0.01). Strong inverse correlations were observed between CD69 expression and NKG2C, NKG2A - NKG2C + , NKG2D, and NKp46 expression on CD56 dim CD16 dim/- NK cells in INRs after ART (NKG2C: r = –0.491, P  = 0.004; NKG2A - NKG2C + : r  = –0.434, P  = 0.013; NKG2D: r  = –0.405, P  = 0.021; NKp46: r  = –0.457, P  = 0.008, respectively). Conclusions INRs had a larger number of CD56 dim CD16 dim/- NK cells characterized by higher activation levels than did IRs after ART. The increase in the CD56 dim CD16 dim/- NK cell subset may play an adverse role in immune reconstitution. Further functional studies of CD56 dim CD16 dim/- NK cells in INRs are urgently needed to inform targeted interventions to optimize immune recovery.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001262
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
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  • 5
    Online Resource
    Online Resource
    Adjunctive sepsis therapy with aminophylline (STAP): a randomized controlled trial
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Chinese Medical Journal Vol. 135, No. 23 ( 2023-01-2), p. 2843-2850
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 135, No. 23 ( 2023-01-2), p. 2843-2850
    Abstract: Sepsis is a serious disease caused by infection. Aminophylline has anti-asthma and anti-inflammatory effects. We aimed to explore the safety and effect of aminophylline in sepsis. Methods: We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit (ICU) admission in two sites. All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline. The primary clinical outcome was all-cause mortality at 28 days. Results: From September 27, 2018 to February 12, 2020, we screened 277 septic patients and eventually enrolled 100 patients, with 50 assigned to the aminophylline group and 50 to the usual-care group. At 28 days, 7 of 50 patients (14.0%) in the aminophylline group had died, compared with 16 of 50 (32.0%) in the usual-care group ( P  = 0.032). Cox regression showed that the aminophylline group had a lower hazard of death (hazard ratio = 0.312, 95% confidence interval: 0.129–0.753). Compared with the usual-care group, patients in the aminophylline group had a longer survival time ( P  = 0.039 by the log-rank test). The effects of aminophylline on vasopressor dose, oxygenation index, and sequential organ failure assessment score were time-dependent with treatment. There were no significant differences in total hospitalization days, ICU hospitalization days, and rates of serious adverse events (all P 〉 0.05). No adverse events were observed in the trial. Conclusions: Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis. Trial registration: ChiCTR.org.cn, ChiCTR1800019173.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000002282
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2108782-9
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  • 6
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    Online Resource
    Trends and characteristics in pre-hospital emergency care in Beijing from 2008 to 2017
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 11 ( 2020-06-5), p. 1268-1275
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 11 ( 2020-06-5), p. 1268-1275
    Abstract: We aimed to describe and analyze the pre-hospital emergency medical service (EMS) in Beijing and provide information for the government and medical institutions to optimize EMS. Methods: We collected all pre-hospital emergency data in Beijing from 2008 to 2017. The chief complaint in each case was classified according to the Medical Priority Dispatch System (MPDS). The sites’ administrative districts were determined through geo-encoding of addresses and then classified into four functional regions. We analyzed the demand for EMS, emergency response times (ERT), and disease spectrum for Beijing as a whole, and for each functional region. Results: A total of 4,192,870 pre-hospital EMS cases met the inclusion criteria, with a significant increase ( P   〈  0.001) of 51.60% from 2008 to 2017. EMS demand was positively associated with population ( r  = 0.946, P   〈  0.001). The pre-hospital EMS demand rate was 1907.05 in 2008 and 2172.23 in 2017 per 100,000, with no significant change ( P  = 0.57). ERT increased significantly ( P  = 0.001), from 19.18 min in 2008 to 24.51 min in 2016. According to MPDS classifications, the demand for pre-hospital care increased for 14 diseases, remained stable for 19, and decreased for only 1 disease. Cases of injury-related disease increased significantly from approximately 90,000 in 2017, accounting for 20% of all pre-hospital EMS cases, and the demand rate decreased in the core region but increased in the sub-urban regions. Cases of heart problems and stroke/transient ischemic attack also increased significantly in the four functional regions, with the highest demand rate in the Core Functional Region. Conclusions: More resources and effort should be devoted to pre-hospital EMS according to the increased pre-hospital EMS demand and prolonged ERT in Beijing over our 10-year study period. Changes in disease spectrum and differences between functional regions should also be considered.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000000770
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 7
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    Online Resource
    Consensus on clinical management of tumor-induced osteomalacia
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Chinese Medical Journal Vol. 134, No. 11 ( 2021-04-1), p. 1264-1266
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 134, No. 11 ( 2021-04-1), p. 1264-1266
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001448
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 8
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    Online Resource
    Comparison of clinical features of nephrotic syndrome after haploidentical and matched donor hematopoietic stem cell transplantation
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Chinese Medical Journal Vol. 137, No. 4 ( 2024-02-20), p. 478-480
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 137, No. 4 ( 2024-02-20), p. 478-480
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000002795
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 9
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    Online Resource
    Repeat mid-urethral sling in management of recurrent or persistent stress urinary incontinence
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 3 ( 2020-01-7), p. 367-368
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 3 ( 2020-01-7), p. 367-368
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000000635
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 10
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    Compromised immune status of patients with post-liver transplant biliary complications
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 21 ( 2020-09-24), p. 2622-2624
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 21 ( 2020-09-24), p. 2622-2624
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001088
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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